Quantification of myocardial hemorrhage using T2* cardiovascular magnetic resonance at 1.5T with ex-vivo validation.
Quantification of myocardial hemorrhage using T2* cardiovascular magnetic resonance at 1.5T with ex-vivo validation.
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DOI：
10.1186/s12968-021-00779-4
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发表时间：
2021-09-30
期刊：
影响因子：
--
通讯作者：
Dharmakumar R
中科院分区：
文献类型：
--
作者：
Chen Y;Ren D;Guan X;Yang HJ;Liu T;Tang R;Ho H;Jin H;Zeng M;Dharmakumar R
T2 ~* 心血管磁共振（CMR）常用于诊断心肌内出血（IMH）。对于用T2* CMR定量IMH，尽管缺乏共识研究，但可互换使用两种不同的方法[受试者特异性T2*（ssT 2 *）和绝对T2* 阈值（aT 2 * < 20 ms）]。我们研究了这些方法是否产生相同的信息。前瞻性招募ST段抬高心肌梗死（STEMI）患者（n = 70），在血运重建后4-7天进行CMR，并进行6个月随访（n = 43）。出于验证目的进行了犬研究，其中动物（n = 20）经受再灌注心肌梗死（MI），MI存活动物（n = 16）在7天和8周时接受CMR，然后实施安乐死。在患者和动物中，使用ssT 2 * 和aT 2 * < 20 ms来确定IMH的T 2 * 和IMH的体积。在动物中，在离体心肌切片上测定离体T2* CMR和质谱法测定铁浓度（[Fe]Hemo）。基于ssT 2 * 和绝对T2* 阈值方法的T2* 值与[Fe]Hemo独立回归并进行比较。测试了一系列T2* 临界值，以确定相对于ssT 2 * 的优化条件。虽然这两种方法有许多相似之处，但也有不同之处。与ssT 2 * 相比，aT 2 * < 20 ms显示患者和动物中IMH的T2* 和体积较低，与MI年龄无关（所有p < 0.005）。虽然两种方法测定的T2* 与[Fe]Hemo高度相关（两种方法的R2 = 0.9），但与aT 2 * < 20 ms相比，ssT 2 * 的回归曲线斜率显著更大（0.46 vs. 0.32，p < 0.01）。此外，与ssT 2 * 相比，稍大的绝对T2* 截止值（患者：23 ms;动物：25 ms）显示出相似的IMH特征。目前的定量方法具有优异的识别顶H的能力，尽管顶H的T2* 和基于aT 2 * < 20 ms的顶H的体积与ssT 2 * 相比更小。因此，用于从T2* CMR量化IMH的方法可能会影响IMH的诊断。在线版本包含补充材料，可通过10.1186/s12968-021-00779-4获得。
T2* cardiovascular magnetic resonance (CMR) is commonly used in the diagnosis of intramyocardial hemorrhage (IMH). For quantifying IMH with T2* CMR, despite the lack of consensus studies, two different methods [subject-specific T2* (ssT2*) and absolute T2* thresholding (aT2* < 20 ms)] are interchangeably used. We examined whether these approaches yield equivalent information. ST elevation myocardial infarction (STEMI) patients (n = 70) were prospectively recruited for CMR at 4–7 days post revascularization and for 6-month follow up (n = 43). Canines studies were performed for validation purposes, where animals (n = 20) were subject to reperfused myocardial infarction (MI) and those surviving the MI (n = 16) underwent CMR at 7 days and 8 weeks and then euthanized. Both in patients and animals, T2* of IMH and volume of IMH were determined using ssT2* and aT2* < 20 ms. In animals, ex-vivo T2* CMR and mass spectrometry for iron concentration ([Fe]Hemo) were determined on excised myocardial sections. T2* values based on ssT2* and absolute T2* threshold approaches were independently regressed against [Fe]Hemo and compared. A range of T2* cut-offs were tested to determine the optimized conditions relative to ssT2*. While both approaches showed many similarities, there were also differences. Compared to ssT2*, aT2* < 20 ms showed lower T2* and volume of IMH in patients and animals independent of MI age (all p < 0.005). While T2* determined from both methods were highly correlated against [Fe]Hemo (R2 = 0.9 for both), the slope of the regression curve for ssT2* was significantly larger as compared to aT2* < 20 ms (0.46 vs. 0.32, p < 0.01). Further, slightly larger absolute T2* cut-offs (patients: 23 ms; animals: 25 ms) showed similar IMH characteristics compared to ssT2*. Current quantification methods have excellent capacity to identify IMH, albeit the T2*of IMH and volume of IMH based on aT2* < 20 ms are smaller compared to ssT2*. Thus the method used to quantify IMH from T2* CMR may influence the diagnosis for IMH. The online version contains supplementary material available at 10.1186/s12968-021-00779-4.
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DOI：
10.1161/circimaging.115.004148
发表时间：
2016-01
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Carrick D;Haig C;Ahmed N;McEntegart M;Petrie MC;Eteiba H;Hood S;Watkins S;Lindsay MM;Davie A;Mahrous A;Mordi I;Rauhalammi S;Sattar N;Welsh P;Radjenovic A;Ford I;Oldroyd KG;Berry C
通讯作者：
Berry C
影响因子：
19.7
作者：
Kali, Avinash;Tang, Richard L. Q.;Dharmakumar, Rohan
通讯作者：
Dharmakumar, Rohan
影响因子：
6.4
作者：
Alkhalil, Mohammad;Borlotti, Alessandra;Choudhury, Robin P.
通讯作者：
Choudhury, Robin P.
影响因子：
14
作者：
Kumar, Andreas;Green, Jordin D.;Friedrich, Matthias G.
通讯作者：
Friedrich, Matthias G.
影响因子：
24
作者：
Stone, Gregg W.;Selker, Harry P.;Ben-Yehuda, Ori
通讯作者：
Ben-Yehuda, Ori