Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability.
Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability.
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DOI：
10.1002/jor.24787
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发表时间：
2021-07
期刊：
影响因子：
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通讯作者：
Fields AJ
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文献类型：
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作者：
Wang L;Han M;Wong J;Zheng P;Lazar AA;Krug R;Fields AJ
软骨终板（CEP）生化成分可能影响椎间盘退变和再生。然而，评估患者的CEP成分仍然是一个挑战。我们使用对CEP水化敏感的超短回波时间（UTE）磁共振成像（MRI）的T2*映射来研究CEP T2*值的空间变化，并确定CEP T2*值与邻近椎间盘退变的相关性。13具人类尸体（56.4±12.7岁）和7名志愿者（36.9±10.9岁）进行了3T MRI，包括UTE和T1ρ定位序列。从UTE图像中生成L4‐S1 cep中T2*值的空间映射，并在子区域之间进行比较。在相邻椎间盘中，比较高T2*值和低T2*值的cep在髓核内的平均T1ρ值。为了评估体内重复性，通过重复扫描测量平均T2*值的精度误差和类内相关系数（ICC）。结果CEP T2*值中央最高，后部最低。在患有轻度至中度Pfirrmann II - III级椎间盘退变的最年轻个体（<50岁）中，低CEP T2*值与严重的椎间盘退变相关：低CEP T2*值的受试者的T1ρ值低26.7% （P = 0.025）。在老年人中，CEP T2*值与椎间盘退变无关（P = 0.39‐0.62）。T2*的精度误差范围为1.7 ~ 2.6 ms，可靠性为良~优（ICC = 0.89 ~ 0.94）。这些发现表明，低T2*值所显示的CEP组成缺陷与轻度至中度椎间盘退变的严重程度有关。用UTE MRI测量CEP T2*值可以阐明CEP成分在轻度至中度椎间盘退变患者中的作用。
Cartilage endplate (CEP) biochemical composition may influence disc degeneration and regeneration. However, evaluating CEP composition in patients remains a challenge. We used T2* mapping from ultrashort echo‐time (UTE) magnetic resonance imaging (MRI), which is sensitive to CEP hydration, to investigate spatial variations in CEP T2* values and to determine how CEP T2* values correlate with adjacent disc degeneration. Thirteen human cadavers (56.4 ± 12.7 years) and seven volunteers (36.9 ± 10.9 years) underwent 3T MRI, including UTE and T1ρ mapping sequences. Spatial mappings of T2* values in L4‐S1 CEPs were generated from UTE images and compared between subregions. In the abutting discs, mean T1ρ values in the nucleus pulposus were compared between CEPs with high vs low T2* values. To assess in vivo repeatability, precision errors in mean T2* values, and intraclass correlation coefficients (ICC) were measured from repeat scans. Results showed that CEP T2* values were highest centrally and lowest posteriorly. In the youngest individuals (<50 years), who had mild‐to‐moderately degenerated Pfirrmann grade II‐III discs, low CEP T2* values associated with severer disc degeneration: T1ρ values were 26.7% lower in subjects with low CEP T2* values (P = .025). In older individuals, CEP T2* values did not associate with disc degeneration (P = .39‐.62). Precision errors in T2* ranged from 1.7 to 2.6 ms, and reliability was good‐to‐excellent (ICC = 0.89‐0.94). These findings suggest that deficits in CEP composition, as indicated by low T2* values, associate with severer disc degeneration during the mild‐to‐moderate stages. Measuring CEP T2* values with UTE MRI may clarify the role of CEP composition in patients with mild‐to‐moderate disc degeneration.