My, oh, MYO9A! Just how complex can regulation of the podocyte actin cytoskeleton get?
My, oh, MYO9A! Just how complex can regulation of the podocyte actin cytoskeleton get?
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我的，哦，MYO9A！
DOI：
10.1016/j.kint.2021.01.006
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发表时间：
2021
影响因子：
19.6
通讯作者：
Schlöndorff,JohannesS
中科院分区：
文献类型：
--
作者：
Schlöndorff,JohannesS
遗传学对肾脏疾病的发展有很大的影响。在肾小球疾病如局灶节段性肾小球硬化症的情况下，涉及十几个基因参与维持和调节足细胞的肌动蛋白细胞骨架。一项新的研究使用人类和小鼠遗传学的组合将非典型肌球蛋白MYO9A添加到该列表中，表明与增强的RhoA活性有关。解开不断增长的肌动蛋白调控网络仍然是理解足细胞病变的一个关键挑战。
Genetics contributes significantly to the development of kidney diseases. In the case of glomerular diseases such as focal segmental glomerulosclerosis, over a dozen genes involved in maintaining and regulating the actin cytoskeleton of podocytes have been implicated. A new study adds the atypical myosin,MYO9A, to that list using a combination of human and mouse genetics, suggesting a link to enhanced RhoA activity. Unraveling the growing web of actin regulators remains a key challenge to understanding podocytopathies.