Exploiting the interactions of aromatic units for folding and assembly in aqueous environments.
Exploiting the interactions of aromatic units for folding and assembly in aqueous environments.
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DOI：
10.1039/c6cc01861k
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发表时间：
2016-06-14
期刊：
影响因子：
--
通讯作者：
Iverson BL
中科院分区：
文献类型：
--
作者：
Ikkanda BA;Iverson BL
各种非共价相互作用（包括氢键、离子相互作用、金属配位和去溶剂化/溶剂化）已被用于将低聚物组织成明确定义的结构。本文描述了利用取代的芳族单元的静电互补性来驱动水性环境中的折叠和组装的芳族折叠体的调查。在了解芳香族相互作用的最新进展的简要描述，其次是利用芳香族单元之间的相互作用，以可预测的方式驱动其组装的折叠体的例子。我们的芳香族折叠体的历史可以追溯到从第一个设计成在水性环境中折叠成褶皱结构的结构到与核酸更相关的异源双链系统。两者合计，结果表明，芳香族单元的静电互补性提供了一个通用的框架驱动可预测的折叠和组装在水性环境中。
A variety of non-covalent interactions (including hydrogen bonding, ionic interactions, metal coordination and desolvation/solvation) have been utilized to organize oligomers into well-defined structures. Herein is described a survey of aromatic foldamers that capitalize on electrostatic complementarity of substituted aromatic units to drive folding and assembly in aqueous environments. A brief description of recent advances in the understanding of aromatic interactions is provided, followed by examples of foldamers that exploit interactions between aromatic units to drive their assembly in predictable fashion. The history of our aromatic foldamers is traced from the first structure designed to fold into a pleated structure in an aqueous environment to a heteroduplex system more related to nucleic acids. Taken together, the results demonstrate that electrostatic complementarity of aromatic units provides a versatile framework for driving predictable folding and assembly in aqueous environments.