Effect of stimulation of nicotinic cholinergic receptors on cortical cerebral blood flow and changes in the effect during aging in anesthetized rats
Effect of stimulation of nicotinic cholinergic receptors on cortical cerebral blood flow and changes in the effect during aging in anesthetized rats
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DOI：
10.1016/s0304-3940(97)00401-1
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发表时间：
1997-06-13
影响因子：
2.5
通讯作者：
Sato, A
中科院分区：
文献类型：
--
作者：
Uchida, S;Kagitani, F;Sato, A
在乌拉坦麻醉的大鼠上，观察了静脉注射尼古丁对皮层脑血流量（CBF）的影响。尼古丁（3-30 μ g/kg）增加皮质CBF，与平均动脉压无关。损毁双侧Meynert基底核（NBM）后，这种反应减弱到对照的一半左右。在阻断毒蕈碱受体后，该反应没有受到显著影响，但在阻断脑实质中的烟碱受体后被消除。它的结论是尼古丁诱导的皮层血管舒张介导的NBM中的烟碱受体的激活，也在大脑皮层。23-26月龄大鼠增加皮层CBF的尼古丁阈剂量发生偏移，32-36月龄大鼠尼古丁引起的皮层CBF增加明显减少。老年人脑内烟碱受体的激活可能促进胆碱能神经血管舒张系统。(C)1997爱思唯尔科学爱尔兰有限公司
The effect of intravenous injection of nicotine on cortical cerebral blood flow (CBF) was examined in urethane anesthetized rats. Nicotine (3-30 mu g/kg) increased cortical CBF, independent of mean arterial pressure. This response was attenuated to about a half of the control one after lesioning the nucleus basalis of Meynert (NBM) bilaterally. The response was not significantly influenced after blocking the muscarinic receptors, but was abolished after blocking the nicotinic receptors in the parenchyma of the brain. It is concluded that the nicotine-induced cortical vasodilation was mediated by activation of the nicotinic receptors in the NBM and also in the cortex of the brain. The threshold dose of nicotine for increasing cortical CBF was shifted in aged rats of 23-26 months, and the nicotine-induced increase in cortical CBF was much reduced in aged rats of 32-36 months. Activation of nicotinic receptors in the brain may aged subjects in facilitating the cholinergic neural vasodilative system. (C) 1997 Elsevier Science ireland Ltd.