Comparison of the homeostasis model assessment and quantitative insulin sensitivity check index with data from forearm metabolic studies for the in vivo assessment of insulin sensitivity
Comparison of the homeostasis model assessment and quantitative insulin sensitivity check index with data from forearm metabolic studies for the in vivo assessment of insulin sensitivity
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DOI：
10.1590/s0100-879x2004000500006
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发表时间：
2004-05-01
影响因子：
2.3
通讯作者：
Foss, M.C.
中科院分区：
文献类型：
--
作者：
Foss-Freitas, M.C.;Foss, M.C.
本研究旨在比较稳态模型评估（HOMA）和定量胰岛素敏感性检查指数（QUICKI）与健康个体和不同病理状态受试者前臂代谢研究的数据。研究了55名健康个体和112名不同病理状态的患者，包括2型糖尿病、原发性高血压等，在禁食一夜和摄入75 g葡萄糖后3小时，采用HOMA、QUICKI和前臂技术结合间接量热法（氧化和非氧化糖代谢）估计肌肉对葡萄糖的摄取。患者HOMA （1.88 +/- 0.14 vs 1.13 +/- 0.10 pmol/l x mmol/l）和胰岛素/葡萄糖（I/G）指数（1.058.9 +/- 340.9 vs 518.6 +/- 70.7 pmol/l x （mg/100 ml前臂）（-1））升高，QUICKI (0.36 +/- 0.004 vs 0.39 +/- 0.006 （muU/ml + mg/dl)(-1)）降低。对整个组（患者和健康个体）数据的分析表明，HOMA对胰岛素抵抗的估计与前臂代谢研究（葡萄糖摄取：r = -0）中获得的数据相关。16, p = 0.04；非氧化糖代谢：r = -0.20。I/G指数：r = 0.17, P = 0.03)。QUICKI与前臂代谢研究数据的比较显示，QUICKI与非氧化糖代谢（r = 0.17, P = 0.03）或I/G指数（r = -0.37, P < 0.0001）具有显著相关性。HOMA和QUICKI是胰岛素敏感性的良好估计，数据来源于前臂代谢研究，涉及胰岛素对肌肉葡萄糖代谢的直接测量。
The present study was designed to compare the homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI) with data from forearm metabolic studies of healthy individuals and of subjects in various pathological states. Fifty-five healthy individuals and 112 patients in various pathological states, including type 2 diabetes mellitus, essential hypertension and others, were studied after an overnight fast and for 3 h after ingestion of 75 g of glucose, by HOMA, QUICKI and the forearm technique to estimate muscle uptake of glucose combined with indirect calorimetry (oxidative and non-oxidative glucose metabolism). The patients showed increased HOMA (1.88 +/- 0.14 vs 1.13 +/- 0.10 pmol/l x mmol/l) and insulin/glucose (I/G) index (1.058.9 +/- 340.9 vs 518.6 +/- 70.7 pmol/l x (mg/100 ml forearm)(-1)), and decreased QUICKI (0,36 +/- 0.004 vs 0.39 +/- 0.006 (muU/ml + mg/dl)(-1)) compared with the healthy individuals. Analysis of the data for the group as a whole (patients and healthy individuals) showed that the estimate of insulin resistance by HOMA was correlated with data obtained in the forearm metabolic studies (glucose uptake: r = -0. 16, P = 0.04; non-oxidative glucose metabolism: r = -0.20. P = 0.01, and I/G index: r = 0.17, P = 0.03). The comparison of QUICKI with data of the forearm metabolic studies showed significant correlation between QUICKI and non-oxidative glucose metabolism (r = 0.17, P = 0.03) or I/G index (r = -0.37, P < 0.0001). The HOMA and QUICKI are good estimates of insulin sensitivity as data derived from forearm metabolic studies involving direct measurements of insulin action on muscle glucose metabolism.