Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery
Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery
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DOI：
10.1016/j.ejmech.2010.08.006
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发表时间：
2010-11-01
影响因子：
6.7
通讯作者：
Khanduja, K. L.
中科院分区：
文献类型：
--
作者：
Jain, Subheet;Kaur, Amanpreet;Khanduja, K. L.
本文研究了G3-COOH聚丙醚亚胺[PETIM]树枝状大分子的急性和亚急性毒性及其作为模型药物酮洛芬缓释载体的应用。制备了药物-树枝状大分子复合物，并通过红外光谱、溶解度和体外释药研究对其进行了表征。发现PETIM树枝状聚合物在A541细胞中的毒性显著低于聚酰胺胺（PAMAM）树枝状聚合物。此外，小鼠中的急性和28天亚急性毒性测量显示，在高达80 mg/kg剂量的PETIM树枝状聚合物下没有死亡率、血液学、生物化学或组织病理学变化。研究结果表明，G3-COOH PETIM树枝状大分子可以作为一种安全有效的药物缓释载体。(C)2010年Elsevier Masson SAS。All rights reserved.
In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery. (C) 2010 Elsevier Masson SAS. All rights reserved.