Near-Infrared-to-Near-Infrared Optical Thermometer BaY2O4: Yb3+/Nd3+ Assembled with Photothermal Conversion Performance
Near-Infrared-to-Near-Infrared Optical Thermometer BaY2O4: Yb3+/Nd3+ Assembled with Photothermal Conversion Performance
复制标题
具有光热转换性能的BaY2O4:Yb3/Nd3组装的近红外到近红外光学测温仪
DOI：
10.1021/acs.inorgchem.2c00432
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发表时间：
2022
影响因子：
4.6
通讯作者：
Jiahua Zhang
中科院分区：
文献类型：
--
作者：
Guotao Xiang;Menglin Yang;Zhen Liu;Yongjie Wang;Sha Jiang;Xianju Zhou;Li Li;Li Ma;Xiaojun Wang;Jiahua Zhang
目前，构建结合实时测温技术的光热治疗剂用于深部组织肿瘤治疗已成为研究热点。在此基础上，研制成功了一种性能优良的光热转换材料BaY 2 O 4：Yb 3 +/Nd 3+，并采用实时光学测温技术进行了组装。通过热耦合Nd ~（3+）：4Fj（j= 7/2，5/2和3/2）的荧光强度比实现了超灵敏温度传感，其最大绝对和相对灵敏度分别为68.88%K ~（-1）和3.29%K ~（-1），超过了绝大多数同类型温度计。特别是，热增强的Nd 3+发光的一个因素为180的检测与照射在980 nm，从声子辅助的能量转移效率的改善。同时，样品的光热转换性能良好，能够破坏病变组织，在恒定功率密度为13.74 mW/mm 2的近红外（NIR）照射180 s后，温度可升至319.3 K。此外，Nd 3+的近红外发射可以在生物组织中达到7 mm的深度，如通过离体实验所确定的。结果表明，BaY 2 O 4：Yb 3 +/Nd 3+作为一种同时具有光热转换和温度传感功能的深部组织PTT剂具有潜在的应用前景。
Nowadays, the construction of photothermal therapy (PTT) agents integrated with real-time thermometry for cancer treatment in deep tissues has become a research hotspot. Herein, an excellent photothermal conversion material, BaY2O4: Yb3+/Nd3+, assembled with real-time optical thermometry is developed successfully. Ultrasensitive temperature sensing is implemented through the fluorescence intensity ratio of thermally coupled Nd3+:4Fj(j= 7/2, 5/2, and 3/2) with a maximal absolute and relative sensitivity of 68.88 and 3.29% K–1, respectively, which surpass the overwhelming majority of the same type of thermometers. Especially, a thermally enhanced Nd3+luminescence with a factor of 180 is detected with irradiation at 980 nm, resulting from the improvement in phonon-assisted energy transfer efficiency. Meanwhile, the photothermal conversion performance of the sample is excellent enough to destroy the pathological tissues, of which the temperature can be raised to 319.3 K after 180 s of near-infrared (NIR) irradiation with an invariable power density of 13.74 mW/mm2. Besides, the NIR emission of Nd3+can reach a depth of 7 mm in the biological tissues, as determined by an ex vivo experiment. All the results show the potential application of BaY2O4: Yb3+/Nd3+as a deep-tissue PTT agent simultaneously equipped with photothermal conversion and temperature sensing function.