Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins.
Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins.
复制标题
神经肌肉突触的乙酰胆碱受体：蛇α-神经毒素检测到的系统发育差异。
DOI：
10.1073/pnas.72.8.3245
复制
发表时间：
1975
影响因子：
11.1
通讯作者：
D. Yoshikami
中科院分区：
文献类型：
--
作者：
S. Burden;H. Hartzell;D. Yoshikami
Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, like those from all other vertebrates previously tested, are blocked by these alpha-neurotoxins. In contrast, receptors from snakes and advanced lizards are insensitive to one or both of the toxins. It is suggested that toxin-resistant acetylcholine receptors appeared early in the evolution of Squamata and preceded the appearance of alpha-neurotoxins.
