Comparison of voluntary ethanol intake by two pairs of rat lines used as genetic models of anxiety
Comparison of voluntary ethanol intake by two pairs of rat lines used as genetic models of anxiety
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DOI：
10.1590/s0100-879x2004001000010
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发表时间：
2004-10-01
影响因子：
2.3
通讯作者：
Takahashi, R.N.
中科院分区：
文献类型：
--
作者：
Da Silva, G.E.;Ramos, A.;Takahashi, R.N.
通过口服乙醇自我给药程序，在两对大鼠品系中研究了焦虑相关行为与自愿乙醇摄入量之间的关系。选择性饲养的Floripa高（H）和低（L）大鼠用于在旷场试验中对比焦虑反应，并使用两种近交系，即自发性高血压大鼠（SHR）和刘易斯大鼠，已知它们在进行几种焦虑/情绪性行为试验时存在显著差异（9-10只动物/系/性别）。在2瓶范例中，未检测到Floripa H和L大鼠在乙醇溶液选择方面的差异（分别为2%，第1-4天和4%，第5-8天）（Floripa H和L大鼠系在第8天的乙醇摄入量分别为1.94 +/- 10.37 vs 1.61 +/- 0.37 g/kg）。与预期相反，较不焦虑的SHR大鼠消耗的乙醇显著多于刘易斯大鼠（在第8天分别摄入2.30 +/- 0.45和0.72 +/- 0.33 g/kg），已知后者既有成瘾倾向又高度焦虑。无论品系如何，雌性大鼠消耗的乙醇比雄性大鼠多（约46%）。结果表明，Floripa H和L大鼠的高度焦虑和自愿摄入乙醇之间没有关系。然而，在SHR和刘易斯大鼠品系中发现这两个变量之间存在负相关。有关焦虑和酒精摄入量之间的关联的文献中的数据在动物模型中是不确定的，但目前的结果表明，因素以外的先天性焦虑增加可能会导致酒精饮酒行为的个体差异。
The relationship between anxiety-related behaviors and voluntary ethanol intake was examined in two pairs of rat lines by the oral ethanol self-administration procedure. Floripa high (H) and low (L) rats selectively bred for contrasting anxiety responses in the open-field test, and two inbred strains, spontaneously hypertensive rats (SHR) and Lewis rats which are known to differ significantly when submitted to several behavioral tests of anxiety/emotionality, were used (9-10 animal s/line/sex). No differences in the choice of ethanol solutions (2%, days 1-4, and 4%, days 5-8, respectively) in a 2-bottle paradigm were detected between Floripa H and L rats (1.94 +/- 10.37 vs 1.61 +/- 0.37 g/kg for ethanol intake on day 8 by the Floripa H and L rat lines, respectively). Contrary to expectations, the less anxious SHR rats consumed significantly more ethanol than Lewis rats (respective intake of 2.30 +/- 0.45 and 0.72 +/- 0.33 g/kg on day 8) which are known to be both addiction-prone and highly anxious. Regardless of strain, female rats consumed more ethanol than males (approximately 46%). The results showed no relationship between high anxiety and voluntary intake of ethanol for Floripa H and L rats. A negative association between these two variables, however, was found for SHR and Lewis rat strains. Data from the literature regarding the association between anxiety and alcohol intake in animal models are not conclusive, but the present results indicate that factors other than increased inborn anxiety probably lead to the individual differences in ethanol drinking behavior.