Tumour necrosis factor-alpha, interleukin-6, and fasting serum insulin correlate with clinical outcome in metastatic breast cancer patients treated with chemotherapy
Tumour necrosis factor-alpha, interleukin-6, and fasting serum insulin correlate with clinical outcome in metastatic breast cancer patients treated with chemotherapy
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DOI：
10.1016/j.cyto.2004.04.002
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发表时间：
2004-07-21
期刊：
影响因子：
3.8
通讯作者：
Savas, B
中科院分区：
文献类型：
--
作者：
Bozcuk, H;Uslu, G;Savas, B
前言：探讨各种生长因子和细胞因子与转移性乳腺癌化疗患者临床预后的关系。方法：对连续接受姑息性化疗的转移性乳腺癌患者的无进展生存期(PFS)和总生存期(OAS)与血清胰岛素、胰岛素抵抗、白介素6(IL-6)和肿瘤坏死因子-α(TNF-α)的关系进行前瞻性评价。结果：雌激素受体(ER)状态、血清IL-6和血清TNF-α是影响PFS的独立因素，RR=0.28(0.13~0.60)，P=0.001，RR=2.481.24~5.61，P=0.012，RR=0.480.23~1.01，P=0.053。多因素分析显示，与OAS相关的因素有组织学分级(RR=7.88(2.33~26.62)，P=0.001)、ER状态(RR=0.18(0.06~0.57，P=0.003)、血清胰岛素(RR=0.87(0.77~0.97)，P=0.016)、血清IL-6(RR=5.99(1.89~18.97)；结论：在转移性乳腺癌患者中，空腹血清胰岛素和肿瘤坏死因子-α水平分别是OAS和PFS的独立预测因子。此外，我们还证实IL-6在这一组中是一个很差的预后指标。这些结果表明，胰岛素和肿瘤坏死因子-α是体内可能直接参与转移性乳腺癌进展的重要生物分子。(C)2004爱思唯尔有限公司。保留所有权利。
Introduction: To assess the relationship of various growth factors and cytokines with the clinical outcome in metastatic breast cancer patients receiving chemotherapy.Methods: Consecutive, metastatic breast cancer patients with measurable disease and receiving palliative chemotherapy were prospectively evaluated for the predictors of progression free survival (PFS) and overall survival (OAS) in relation to serum insulin, insulin resistance, interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha).Results: Estrogen receptor (ER) status, serum IL-6 and serum TNF-alpha were the independent determinants of PFS, with RR = 0.28 (0.13-0.60), P = 0.001, RR = 2.48 (1.24-5.61), P = 0.012, and RR = 0.48 (0.23-1.01), P = 0.053, respectively. The factors related with OAS in the multivariate analysis were histological grade (RR = 7.88 (2.33-26.62), P = 0.001), ER status (RR = 0.18 (0.06-0.57), P = 0.003), serum insulin (RR = 0.87 (0.77-0.97), P = 0.016), and serum IL-6 (RR = 5.99 (1.89-18.97), P = 0.002).Conclusions: We show for the first time that fasting serum insulin and TNF-a levels are independent predictors for OAS and PFS, respectively, in metastatic breast cancer patients. In addition, we also confirm that IL-6 is a poor prognosticator in this group. These results suggest that insulin and TNF-alpha are important biomolecules that may be directly involved in vivo in the progression of metastatic breast cancer. (C) 2004 Elsevier Ltd. All rights reserved.