Very high serum ferritin levels in three newborns with Kawasaki-like illness
Very high serum ferritin levels in three newborns with Kawasaki-like illness
复制标题
DOI：
10.1093/pch/17.4.201
复制
发表时间：
2012-04-01
影响因子：
1.9
通讯作者：
Hamdan, Mohamed A.
中科院分区：
文献类型：
--
作者：
Nasir, Arwa;Al Tatari, Hosam;Hamdan, Mohamed A.
川崎病(KD)是一种病因不明的炎症性疾病，影响儿童，在生命的第二年发病率最高。KD在出生第一年并不常见，在新生儿期也很少见。本报告描述了三名因发热而入院的新生儿，其全身炎症的临床特征几乎相同。这些表现不符合KD的标准；然而，所有三名患者对静脉注射免疫球蛋白治疗都有迅速和完全的反应。具体地说，这些表现与非常高的血清铁蛋白水平有关。作者认为，这种临床综合征是KD的一种变异型，血清铁蛋白水平可能是诊断KD及其变异型的有用标志物。此外，这种临床表现与非常高的血清铁蛋白水平的相关性增加了与噬血细胞性淋巴组织细胞增多症有关的可能性。
Kawasaki disease (KD) is an inflammatory condition of unknown etiology that affects children, with a peak incidence in the second year of life. KD is uncommon in the first year of life and is rare in the newborn period.The present report describes three newborn infants who were admitted to hospital with fever and nearly identical clinical features of generalized inflammation. The presentations did not meet the criteria for KD; however, all three patients responded promptly and completely to intravenous immunoglobulin treatment. Specifically, the association of these presentations with very high levels of serum ferritin is reported. The authors propose that this clinical syndrome represents a variant of KD, and that serum ferritin level may be a useful marker in diagnosing KD and its variants. Additionally, the association of this clinical picture with very high serum ferritin levels raises the possibility of a link with hemophagocytic lymphohistiocytosis.