Tissue localization of nerve growth factor and nerve growth factor receptors.
Tissue localization of nerve growth factor and nerve growth factor receptors.
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DOI：
10.1007/978-3-642-75747-1_4
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发表时间：
1991
影响因子：
--
通讯作者：
M. Bothwell
中科院分区：
文献类型：
--
作者：
M. Bothwell
列维-蒙塔尔奇尼及其同事的开创性研究证实，神经生长因子（NGF）是外周神经系统神经元的重要生理调节剂。毫无疑问，部分原因是由于免疫化学剥夺啮齿动物的NGF对交感和感觉神经系统产生的戏剧性和特异性影响（Levi-MontalciniandBooker1960;Johnsonet al. 1983）， NGF的作用仅针对这些周围神经元的观念变得根深蒂固。一种功能模型认为神经生长因子是由感觉和交感神经支配的靶点产生的，调节轴突生长对靶点的特异性以及找到正确靶点的神经元的存活，这种模型被武断地接受。在过去的几年里，很明显，这些概念只是部分正确的。在很大程度上，通过改进表征NGF及其受体表达位点的方法，已经表明NGF作用的生物学比最初想象的要复杂得多。
The pioneering investigations ofLevi-Montalciniand coworkers established that nerve growth factor (NGF) is an important physiological regulator of neurons of the peripheral nervous system. No doubt in part because of the dramatic and specific effects on the sympathetic and sensory nervous system resulting from immunochemically depriving rodents of NGF (Levi-MontalciniandBooker1960;Johnsonet al. 1983), the notion that the action of NGF was directed exclusively to these peripheral neurons became firmly entrenched. A functional model which proposed that NGF was produced by targets of sensory and sympathetic innervation, regulating the specificity of axon growth to the target and the survival of neurons which found the correct target, became dogmatically accepted. Over the last few years it has become clear that these concepts are only partially correct. Aided in substantial part by improved methods for characterization of sites of expression of NGF and its receptor, it has been shown that the biology of NGF action is much more complicated than was initially imagined.