Elicitation of delayed allergic skin reactions with haptens; the dependence of elicitation on hapten combination with protein.
Elicitation of delayed allergic skin reactions with haptens; the dependence of elicitation on hapten combination with protein.
复制标题
引起延迟与触发的过敏性皮肤反应；诱导对蛋白质组合的诱导依赖性。
DOI：
10.1084/jem.95.5.473
复制
发表时间：
1952-05-01
期刊：
影响因子：
--
通讯作者：
BELMAN S
中科院分区：
文献类型：
--
作者：
EISEN HN;ORRIS L;BELMAN S
研究了8种构型均匀性较高的2，4-二硝基苯基化合物在豚鼠和先前暴露于2，4-二硝基氟苯致敏的人中引起迟发性皮肤过敏反应的能力。八种化合物中有四种产生反应（激发子），另外四种没有（非激发子）。结果表明，诱导子在体内外均能与蛋白质结合。然而，在这两种情况下，非诱导剂都未能联合收割机。它的结论是，半抗原的迟发性过敏性皮肤反应的诱发的必要条件是后者与皮肤蛋白通过共价键类型的形成的组合。在提出来解释蛋白质结合的强制性特征的几种可能的解释中，还没有选择的可能。
Eight 2,4-dinitrophenyl compounds with a high degree of configurational uniformity were examined in regard to their ability to elicit delayed allergic skin reactions in guinea pigs and men who had been sensitized by previous exposure to 2,4-dinitrofluorobenzene. Four of the eight compounds produced reactions (elicitors) and four others did not (non-elicitors). It was found that the elicitors combined with protein in vitro and in vivo. The non-elicitors, however, failed to combine in either situation. It is concluded that a necessary condition for the elicitation of delayed allergic skin reactions by haptens is the combination of the latter with skin protein through the formation of bonds of the covalent type. No choice is yet possible amongst the several possible explanations which are advanced to account for the obligatory character of protein combination.