PARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation?
PARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation?
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DOI：
10.1002/bies.10179
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发表时间：
2002-11-01
期刊：
影响因子：
4
通讯作者：
Grune, T
中科院分区：
文献类型：
--
作者：
Arnold, J;Grune, T
在有氧生活的进化过程中，抗氧化防御系统发展，直接防止细胞成分的氧化修饰或去除修饰的成分。后者的一个例子是蛋白酶体，它去除细胞溶质氧化蛋白。最近，发现了一种新的激活核20 S蛋白酶体的机制：自动修饰的聚（ADP-核糖）聚合酶-1（PARP-1）激活蛋白酶体，以促进氧化损伤的组蛋白的选择性降解。由于PARP-1本身的激活是由DNA损伤诱导的，并且应该在DNA修复中发挥作用，因此这些新结果表明PARP-1在去除氧化核蛋白和DNA修复中的联合作用。我们假设PARP-1可以提供两个核抗氧化防御系统之间的协调联系，其协同激活将在氧化应激后快速有效地恢复天然染色质结构。(C)2002 Wiley Periodicals，Inc.
During the evolution of aerobic life, antioxidant defence systems developed that either directly prevent oxidative modifications of the cellular constituents or remove the modified components. An example of the latter is the proteasome, which removes cytosolic oxidised proteins. Recently, a novel mechanism of activation of the nuclear 20S proteasome was discovered: automodified poly(ADP-ribose) polymerase-1 (PARP-1) activates the proteasome to facilitate selective degradation of oxidatively damaged histones. Since activation of the PARP-1 itself is induced by DNA damage and is supposed to play a role in DNA repair, these new results suggest a joint role of PARP-1 in the removal of oxidised nucleoproteins and in DNA repair. We hypothesise that PARP-1 could provide a co-ordinative link between two nuclear antioxidant defence systems, whose concerted activation would produce a fast and efficient restoration of the native chromatin structure following oxidative stress. (C) 2002 Wiley Periodicals, Inc.