Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients
Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients
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DOI：
10.1016/j.metabol.2011.06.023
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发表时间：
2012-02-01
影响因子：
9.8
通讯作者：
Shimatsu, Akira
中科院分区：
文献类型：
--
作者：
Himeno, Akihiro;Satoh-Asahara, Noriko;Shimatsu, Akira
下丘脑-垂体-肾上腺（HPA）轴的失调可增加心血管疾病（CVD）的风险。然而，HPA轴活性与肥胖患者体重减轻和心血管疾病危险因素的详细关系尚未得到研究。本研究旨在阐明肥胖患者唾液皮质醇水平与体重减轻和心血管疾病危险因素的关系。作为HPA轴活动的标志，我们测量了83名日本肥胖门诊患者的早晨唾液皮质醇水平。我们还检查了代谢参数、炎症标志物和动脉硬度指标，即脉搏波速度和心踝血管指数。所有83例肥胖患者均接受了3个月的减肥治疗和生活方式改变。在基线时，多变量回归分析显示，只有c反应蛋白的对数转化（β = 0.258, P < 0.05）和心踝血管指数（β = 0.233, P < 0.05）是唾液皮质醇水平的独立决定因素。然而，其他代谢参数与唾液皮质醇水平无显著相关。此外，较低的唾液皮质醇水平和较高的基线体重是通过减肥治疗成功减肥的唯一独立决定因素（P < 0.01）。目前的研究表明，在肥胖患者中，早晨唾液皮质醇的基线水平与炎症标志物、动脉僵硬度和成功减肥的水平显著相关。因此，唾液皮质醇可能是评估和管理肥胖患者体重和心血管疾病危险因素的有用标志物。(C) 2012爱思唯尔公司版权所有。
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis can increase the risk of cardiovascular disease (CVD). However, the detailed relationships of HPA axis activity with weight reduction and CVD risk factors in obese patients have not been examined. This study was designed to elucidate the associations of salivary cortisol levels with weight reduction and CVD risk factors in obese patients. As a marker of HPA axis activity, we measured the morning salivary cortisol levels of 83 obese Japanese outpatients. We also examined metabolic parameters, inflammatory markers, and indicators of arterial stiffness, that is, the pulse wave velocity and cardio-ankle vascular index. All 83 obese patients underwent 3-month weight reduction therapy with lifestyle modification. At the baseline, multivariate regression analysis revealed that only logarithmic transformation of C-reactive protein (beta = 0.258, P < .05) and cardio-ankle vascular index (beta = 0.233, P < .05) were independent determinants of the salivary cortisol levels. However, other metabolic parameters were not significantly associated with the salivary cortisol levels. In addition, lower salivary cortisol levels and higher body weight at the baseline were the only independent determinants of successful weight loss through the weight reduction therapy (P < .01). The present study demonstrates that the baseline morning salivary cortisol levels are significantly associated with the levels of an inflammatory marker, arterial stiffness, and successful weight reduction in obese patients. Therefore, salivary cortisol could be a useful marker for assessing and managing body weight and CVD risk factors in obese patients. (C) 2012 Elsevier Inc. All rights reserved.