ACPR, a STE12 homologue from Candida albicans, is a strong inducer of pseudohyphae in Saccharomyces cerevisiae haploids and diploids.
ACPR, a STE12 homologue from Candida albicans, is a strong inducer of pseudohyphae in Saccharomyces cerevisiae haploids and diploids.
复制标题
ACPR 是来自白色念珠菌的 STE12 同源物，是酿酒酵母单倍体和二倍体中假菌丝的强诱导剂。
DOI：
10.1006/bbrc.1994.2776
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发表时间：
1994
影响因子：
3.1
通讯作者：
Datta,A
中科院分区：
文献类型：
--
作者：
Singh,P;Ganesan,K;Malathi,K;Ghosh,D;Datta,A
白色念珠菌ACPR编码一种与该酵母分泌性酸性蛋白酶抗原相关的蛋白。其氨基末端结构域与酿酒酵母STE12的氨基末端DNA结合结构域高度相似，STE12参与单倍体的交配和二倍体假菌丝的形成，ACPR（或其DNA结合结构域置换为STE12）可支持二倍体假菌丝的形成。然而，与STE12不同的是，这些构建体影响了出芽模式，并诱导假菌丝的形成，并且这种诱导与培养基的氮状况无关。白色念珠菌
ACPRfromCandida albicansencodes a protein antigenically related to the secretory acid proteinase of this yeast. Its amino terminal domain is highly similar to the amino terminal, DNA-binding domain of STE12 ofSaccharomyces cerevisiae.STE12is involved in mating of haploids and in pseudohyphae formation in diploids.ACPR, or its DNA-binding domain swapped intoSTE12, can support pseudohyphae formation inS. cerevisiaediploids. However, unlikeSTE12, these constructs affect the budding pattern and induce pseudohyphae formation inS. cerevisiaehaploids as well, and this induction is independent of the nitrogen status of the medium.ACPRappears to be a stronger inducer of pseudohyphae thanSTE12and is likely to be involved in the formation of pseudohyphae and hyphae inC. albicans.