Chronic hepatitis B virus (HBV) infection in children: 25 years' experience
Chronic hepatitis B virus (HBV) infection in children: 25 years' experience
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DOI：
10.1111/jvh.12019
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发表时间：
2013-04-01
影响因子：
2.5
通讯作者：
Roberts, E. A.
中科院分区：
文献类型：
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作者：
Popalis, C.;Yeung, L. T. F.;Roberts, E. A.
而e-血清转换表示B e-抗原（HBeAg）的丧失，随后是HBeAg抗体（抗-HBe）的获得，“非活动性慢性感染”将这一概念扩展到包括血清病毒载量降低和生化缓解的e-血清转换。在评价治疗结果之前，必须对这些事件进行充分表征。我们研究了慢性HBV感染儿童的e-血清转换率和非活动性慢性感染的实现。从1983年至2008年，回顾性地从儿童医院肝病门诊确定了HBsAg阳性> 6个月的儿童。非活动性慢性感染定义为HBeAg、血清ALT 40 IU/mL和HBV DNA丢失
Whereas e-seroconversion represents the loss of hepatitis B e-antigen (HBeAg) followed by gain of antibody to HBeAg (anti-HBe), inactive chronic infection' extends this concept to include e-seroconversion with decreased serum viral load and biochemical remission. These events must be well-characterized before treatment outcomes can be evaluated. We examined the rates of e-seroconversion and achievement of inactive chronic infection among children with chronic HBV infection. Children who were HBsAg positive >6months were identified retrospectively between 1983 and 2008 from the Hospital for Sick Children Liver Clinic. Inactive chronic infection was defined as loss of HBeAg, serum ALT 40IU/mL, and HBV DNA