Proline-directed kinase systems in Alzheimer's disease pathology.
Proline-directed kinase systems in Alzheimer's disease pathology.
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阿尔茨海默病病理学中脯氨酸导向的激酶系统。
DOI：
10.1016/0304-3940(93)90445-q
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发表时间：
1993
影响因子：
2.5
通讯作者：
Zinsmeister,P
中科院分区：
文献类型：
--
作者：
Wood,JG;Lu,Q;Reich,C;Zinsmeister,P
免疫组织化学分析用于评估脯氨酸定向激酶cdc2在阿尔茨海默病（AD）病理中的分布。一个强大的信号是最突出的神经元缠结（NFT）的受影响的神经元，也含有异常磷酸化的tau蛋白。生化分析鉴定出牛脑微管中含有正常tau蛋白的cdc2库。这些结果强烈支持了cdc 2参与AD病理学中tau异常磷酸化的假设，并且它们提出了有关正常和患病神经元中tau磷酸化调节的重要问题。
Immunohistochemical analysis was used to assess the distribution of the proline-directed kinase, cdc2, in Alzheimer's disease (AD) pathology. A robust signal was most prominent in the neurofibrillary tangle (NFT) of affected neurons that also contained abnormally phosphorylated tau protein. Biochemical analysis identified a pool of cdc2 in bovine brain microtubules that contain normal tau. These results strongly support the hypothesis that cdc2 is involved in the abnormal phosphorylation of tau in AD pathology and they raise important issues regarding regulation of tau phosphorylation in normal and diseased neurons.