Hormonal and cytokine effects of uric acid.
Hormonal and cytokine effects of uric acid.
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尿酸的激素和细胞因子效应。
DOI：
10.1097/01.mnh.0000199010.33929.7f
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发表时间：
2006
影响因子：
3.2
通讯作者：
Herrera-Acosta,Jaime
中科院分区：
文献类型：
--
作者：
Sánchez-Lozada,LauraG;Nakagawa,Takahiko;Kang,Duk-Hee;Feig,DanI;Franco,Martha;Johnson,RichardJ;Herrera-Acosta,Jaime
可溶性尿酸具有重要的生物学作用。虽然它作为一种抗氧化剂，也有证据表明，尿酸对VSMC具有促炎和增殖作用，并导致内皮细胞功能障碍。这些细胞机制可能解释了为什么尿酸与肾脏和心血管疾病相关。
Soluble uric acid has important biologic roles. While it acts as an antioxidant, there is also evidence that uric acid has pro-inflammatory and proliferative effects on VSMC, and causes dysfunction of endothelial cells. These cellular mechanisms may translate into why uric acid is associated with renal and cardiovascular disease.