In-phantom two-dimensional thermal neutron distribution for intraoperative boron neutron capture therapy of brain tumours
In-phantom two-dimensional thermal neutron distribution for intraoperative boron neutron capture therapy of brain tumours
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DOI：
10.1088/0031-9155/47/14/302
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发表时间：
2002-07-21
影响因子：
3.5
通讯作者：
Nose, T
中科院分区：
文献类型：
--
作者：
Yamamoto, T;Matsumura, A;Nose, T
本研究的目的是确定术中硼中子捕获治疗（IOBNCT）中中子束产生的幻体内热中子分布。在日本4号研究堆中，采用超低温束（ENB）和混合超低温束（TNB-1）辐照，将金激活线布置在一个圆柱形水模中，其中有（空模中）或没有（标准模）圆柱形苯乙烯形式。与使用TNB-1的结果相比，使用ENB时，我们观察到热中子通量分布趋平，热中子通量在深度处的传递明显增强。ENB和TNB-1产生的热中子分布在空腔内均有明显改善，在空腔外侧形成双高剂量区。结合ENB和空腔内腔观察到空腔周围呈扁平状分布。测量数据表明，ENB可能以增强和平坦的剂量递送到术后腔的边缘组织的形式提供临床优势，其中残留和/或显微镜下浸润性肿瘤经常发生。超热中子束与IOBNCT的结合将提高BNCT治疗脑肿瘤的临床效果。
The aim of this study was to determine the in-phantom thermal neutron distribution derived from neutron beams for intraoperative boron neutron capture therapy (IOBNCT). Gold activation wires arranged in a cylindrical water phantom with (void- in-phantom) or without (standard phantom) a cylinder styrene form placed inside were irradiated by using the epithermal beam (ENB) and the mixed thermal-epithermal beam (TNB-1) at the Japan Research Reactor No 4. With ENB, we observed a flattened distribution of thermal neutron flux and a significantly enhanced thermal flux delivery at a depth compared with the results of using TNB-1. The thermal neutron distribution derived from both the ENB and TNB-1 was significantly improved in the void-in-phantom, and a double high dose area was formed lateral to the void. The flattened distribution in the circumference of the void was observed with the combination of ENB and the void- in-phantom. The measurement data suggest that the ENB may provide a clinical advantage in the form of an enhanced and flattened dose delivery to the marginal tissue of a post-operative cavity in which a residual and/or microscopically infiltrating tumour often occurs. The combination of the epithermal neutron beam and IOBNCT will improve the clinical results of BNCT for brain tumours.