PROGRESSIVE HYPERPHOSPHORYLATION OF NEUROFILAMENT HEAVY SUBUNITS WITH AGING - POSSIBLE INVOLVEMENT IN THE MECHANISM OF NEUROFILAMENT ACCUMULATION
PROGRESSIVE HYPERPHOSPHORYLATION OF NEUROFILAMENT HEAVY SUBUNITS WITH AGING - POSSIBLE INVOLVEMENT IN THE MECHANISM OF NEUROFILAMENT ACCUMULATION
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DOI：
10.1006/bbrc.1995.2475
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发表时间：
1995-10-04
影响因子：
3.1
通讯作者：
LETERRIER, JF
中科院分区：
文献类型：
--
作者：
GOU, JP;EYER, J;LETERRIER, JF
在正常衰老和与年龄相关的神经退行性疾病中都会出现磷酸化神经丝的异常堆积。在目前的工作中，我们研究了从控制年龄的大鼠分离的神经细丝的物理化学性质。衰老在体内诱导重神经细丝亚单位的过度磷酸化，而不影响神经细丝相关蛋白激酶在体外的神经细丝磷酸化。在体外，高龄大鼠的神经丝之间的相互作用比年轻动物的神经丝发生的速度和程度都要高。这些结果支持这一假说，即在衰老的哺乳动物神经组织中观察到的神经细丝的异常聚集是相互连接的和独立的神经细丝之间的原位平衡改变的结果。(C)1995年学术出版社。
Abnormal accumulations of phosphorylated neurofilaments occur both in normal senescence and in age-associated neurodegenerative diseases. In the present work, we study the physicochemical properties of neurofilaments isolated from rats of controlled ages. Aging induces in vivo hyperphosphorylation of the heavy neurofilament subunit without affecting in vitro neurofilament phosphorylation by the neurofilament-associated protein kinase. Interactions in vitro between neurofilaments from very old rats occur at higher rate and extent than that of neurofilaments from younger animals. These results support the hypothesis that the abnormal accumulation of neurofilaments observed in nervous tissues from aging mammals results from an altered equilibrium in situ between interconnected and independent neurofilaments. (C) 1995 Academic Press, Inc.