Actin-Binding Proteins in Cardiac Hypertrophy.
Actin-Binding Proteins in Cardiac Hypertrophy.
复制标题
心肌肥厚中的肌动蛋白结合蛋白
DOI：
10.3390/cells11223566
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发表时间：
2022-11-11
期刊：
影响因子：
6
通讯作者：
Ren, Zhanhong
中科院分区：
文献类型：
--
作者：
Pan, Congbin;Wang, Siqi;Liu, Chao;Ren, Zhanhong
The heart reacts to a large number of pathological stimuli through cardiac hypertrophy, which finally can lead to heart failure. However, the molecular mechanisms of cardiac hypertrophy remain elusive. Actin participates in the formation of highly differentiated myofibrils under the regulation of actin-binding proteins (ABPs), which provides a structural basis for the contractile function and morphological change in cardiomyocytes. Previous studies have shown that the functional abnormality of ABPs can contribute to cardiac hypertrophy. Here, we review the function of various actin-binding proteins associated with the development of cardiac hypertrophy, which provides more references for the prevention and treatment of cardiomyopathy.
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