Lack of Reduction in Racial Disparities in Cancer-Specific Mortality Over a 20-Year Period
Lack of Reduction in Racial Disparities in Cancer-Specific Mortality Over a 20-Year Period
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DOI：
10.1002/cncr.28617
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发表时间：
2014-05-15
期刊：
影响因子：
6.2
通讯作者：
Nguyen, Paul L.
中科院分区：
文献类型：
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作者：
Aizer, Ayal A.;Wilhite, Tyler J.;Nguyen, Paul L.
据作者所知，目前尚不清楚癌症结局中基于种族的差异是否随时间而改变。在目前的研究中，作者评估了在过去的20年中，癌症特异性死亡率的种族差异是否有所改善。方法监测、流行病学和最终结果项目用于确定1988年至2007年期间诊断为肺癌、乳腺癌、前列腺癌或结直肠癌（男女癌症相关死亡率的前3位原因）的2，713，474例患者。排除后，1，001，978例患者仍有资格进行分析。使用Fine和Gray回归模型评估了种族对癌症特异性死亡率的影响;交互作用模型评估了随时间的趋势。
BACKGROUNDTo the authors' knowledge, it remains unknown whether race-based differences in cancer outcomes have changed with time. In the current study, the authors assessed whether racial disparities in cancer-specific mortality have improved over the last 20 years.METHODSThe Surveillance, Epidemiology, and End Results program was used to identify 2,713,474 patients diagnosed between 1988 and 2007 with either lung, breast, prostate, or colorectal cancer (the leading 3 causes of cancer-related mortality among each sex). After exclusions, 1,001,978 patients remained eligible for analysis. The impact of race on cancer-specific mortality was assessed using the regression model of Fine and Gray; an interaction model evaluated trends over time.RESULTSAfrican Americans presented with a more advanced stage of disease (P