Infection of mouse teratocarcinoma stem cells with influenza virus: normal expression of proteins derived from spliced messenger RNAs.
Infection of mouse teratocarcinoma stem cells with influenza virus: normal expression of proteins derived from spliced messenger RNAs.
复制标题
流感病毒感染小鼠畸胎瘤干细胞：剪接信使 RNA 衍生的蛋白质正常表达。
DOI：
10.1016/0012-1606(83)90108-2
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发表时间：
1983
影响因子：
2.7
通讯作者：
Lamb,RA
中科院分区：
文献类型：
--
作者：
Strickland,S;Lamb,RA
小鼠畸胎瘤干细胞诱导分化前后均感染流感病毒。这种病毒能够感染细胞，而不管分化状态如何。此外，已知从剪接的信使RNA翻译的病毒编码蛋白质在感染细胞中以正常量产生，并且这种表达也不依赖于分化。这些结果表明，干细胞和它们的分化后代都可以有效地剪接这些流感病毒信使的前体RNA。
Mouse teratocarcinoma stem cells before and after induction of differentiation have been infected with influenza virus. This virus is able to infect the cells irrespective of the state of differentiation. In addition, viral-encoded proteins that are known to be translated from spliced messenger RNAs are produced in normal amounts in the infected cells, and this expression is also independent of differentiation. These results indicate that both the stem cells and their differentiated progeny can efficiently splice the precursor RNAs for these influenza virus messengers.