Plasma quality after whole-blood filtration depends on storage temperature and filter type
Plasma quality after whole-blood filtration depends on storage temperature and filter type
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DOI：
10.1111/j.0958-7578.2004.00517.x
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发表时间：
2004-08-01
影响因子：
1.5
通讯作者：
Seitz, R
中科院分区：
文献类型：
--
作者：
Heiden, M;Salge, U;Seitz, R
该研究评估了用四种不同的聚酯过滤器和一种聚氨酯过滤器过滤全血后获得的血浆质量。在所有的实验中，凝血因子和蛋白酶抑制剂的活性不受过滤的影响或只有微不足道的影响。过滤没有增加凝血和纤溶的标志物。仅观察到强烈的中性粒细胞和补体活化，这取决于过滤器的类型和全血储存条件。然而，由于中性粒细胞弹性酶特异性降解产物没有增加，补体衍生的过敏毒素C3a以其灭活形式存在，C3a- desarg，这些过滤依赖性的变化显然对全血过滤新鲜冷冻血浆输注的治疗质量影响不大。
The study evaluated the quality of plasma obtained after whole-blood filtration with four different polyester filters and one polyurethane filter. The activities of coagulation factors and proteinase inhibitors were not or only negligibly affected by filtration, in all experiments. Filtration did not increase markers of clotting and fibrinolysis. Only a strong neutrophil and complement activation was observed, which depended on the type of filter and whole-blood storage conditions. However, as neutrophil elastase-specific degradation products did not increase and the complement-derived anaphylatoxin C3a was found in its inactivated form, C3a-desArg, these filtration-dependent changes apparently have little impact on the therapeutic quality of whole-blood-filtered fresh frozen plasma for transfusion.