Endocannabinoids and immune regulation.
Endocannabinoids and immune regulation.
复制标题
DOI：
10.1016/j.phrs.2009.03.019
复制
发表时间：
2009-08
影响因子：
9.3
通讯作者：
Nagarkatti, Prakash
中科院分区：
文献类型：
--
作者：
Pandey, Rupal;Mousawy, Khalida;Nagarkatti, Mitzi;Nagarkatti, Prakash
近年来，随着大麻素受体的发现，大麻素类药物的药理学取得了重要进展。这些发现加深了我们对外源性和内源性大麻素信号的理解，并探索了它们的生物合成、分子结构、失活及其受体在体内的解剖分布的各种途径。内源性大麻素系统参与免疫调节和神经保护。本文综述了内源性大麻素调节免疫应答的可能机制，包括调节不同细胞类型的免疫应答、对细胞因子网络的影响、诱导免疫细胞的凋亡以及下调固有免疫应答和获得性免疫应答。我们实验室的研究表明，给予内源性大麻素或使用分解内源性大麻素的酶抑制剂，会导致免疫抑制，并从免疫介导的器官损伤中恢复过来，如肝脏。因此，体内操纵内源性大麻素可能构成抗炎症性疾病的一种新的治疗方式。
Cannabinoid pharmacology has made important advances in recent years after the discovery of the cannabinoid receptors. These discoveries have added to our understanding of exogenous and endogenous cannabinoid signaling along with exploring the various pathways of their biosynthesis, molecular structure, inactivation, and anatomical distribution of their receptors throughout the body. The endocannabinoid system is involved in immunoregulation and neuroprotection. In this article, we have reviewed the possible mechanisms of the regulation of the immune response by endocannabinoids which include modulation of immune response in different cell types, effect on cytokine network, induction of apoptosis in immune cells and downregulation of innate and adaptive immune response. Studies from our laboratory have suggested that administration of endocannabinoids or use of inhibitors of enzymes that breakdown the endocannabinoids, leads to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Thus, manipulation of endocannabinoids in vivo may constitute a novel treatment modality against inflammatory disorders.
登录
查看更多内容
影响因子：
4.8
作者：
Bifulco, M;Laezza, C;Di Marzo, V
通讯作者：
Di Marzo, V
影响因子：
3.6
作者：
Carrier, EJ;Kearn, CS;Hillard, CJ
通讯作者：
Hillard, CJ
影响因子：
6.1
作者：
CABRAL, GA;TONEY, DM;MARCIANOCABRAL, F
通讯作者：
MARCIANOCABRAL, F
影响因子：
11.2
作者：
Blázquez, C;González-Feria, L;Guzmán, M
通讯作者：
Guzmán, M
影响因子：
3.3
作者：
Achiron, A;Miron, S;Biegon, A
通讯作者：
Biegon, A