Sevum uric acid and cardiovascular mortality - The NHANES I epidemiologic follow-up study, 1971-1992
Sevum uric acid and cardiovascular mortality - The NHANES I epidemiologic follow-up study, 1971-1992
复制标题
DOI：
10.1001/jama.283.18.2404
复制
发表时间：
2000-05-10
影响因子：
120.7
通讯作者：
Alderman, MH
中科院分区：
文献类型：
--
作者：
Fang, J;Alderman, MH
背景尽管许多流行病学研究表明血清尿酸水平升高是心血管死亡的危险因素，目的探讨血尿酸水平与心血管疾病死亡率的关系。方法：对第一次全国健康与营养检查调查的流行病学随访资料进行横断面人群研究（NHANES I），1971-1975年（基线）和来自NHANES I流行病学随访研究（NHEFS）的数据。参与者共有5926名年龄在25至74岁并且在基线时具有血清尿酸水平测量的受试者。主要结果测量缺血性心脏病死亡率、总心血管死亡率和全因死亡率，结果平均随访16.4年，死亡1593例，其中心血管疾病死亡731例（45.9%），血尿酸水平升高与心血管疾病死亡率呈正相关，男性和女性、黑人和白色人均为如此。当血清尿酸水平处于最高四分位数时，男性和女性因缺血性心脏病死亡的人数均高于处于最低四分位数时（男性，>416 vs 333 vs 333）。
Context Although many epidemiological studies have suggested that increased serum uric acid levels are a risk factor for cardiovascular mortality, this relationship remains uncertain.Objective To determine the association of serum uric acid levels with cardiovascular mortality.Design and Setting Cross-sectional population-based study of epidemiological follow-up data from the First National Health and Nutrition Examination Survey (NHANES I) from 1971-1975 (baseline) and data from NHANES I Epidemiologic Follow-up Study (NHEFS).Participants A total of 5926 subjects who were aged 25 to 74 years and had serum uric acid level measurements at baseline.Main Outcome Measures Ischemic heart disease mortality, total cardiovascular mortality, and all-cause mortality, compared by quartiles of serum uric acid level.Results In an average of 16.4 years of follow-up, 1593 deaths occurred, of which 731 (45.9%) were ascribed to cardiovascular disease, Increased serum uric acid levels had a positive relationship to cardiovascular mortality in men and women and in black and white persons. Deaths due to ischemic heart disease in both men and women increased when serum uric acid levels were in the highest quartile compared with the lowest quartile (men, >416 vs 333 vs