Donor Indocyanine Green Clearance Test Predicts Graft Quality and Early Graft Prognosis After Liver Transplantation
Donor Indocyanine Green Clearance Test Predicts Graft Quality and Early Graft Prognosis After Liver Transplantation
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供体吲哚菁绿清除率测试可预测肝移植后的移植物质量和早期移植物预后
DOI：
10.1007/s10620-017-4765-x
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发表时间：
2017-11-01
影响因子：
3.1
通讯作者：
He, Xiaoshun
中科院分区：
文献类型：
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作者：
Tang, Yunhua;Han, Ming;He, Xiaoshun
背景器官移植中心非常重视供体的可获得性。然而，没有可靠的定量方法已被用来准确评估移植前移植物的质量。在这里，我们报告说，吲哚菁绿色（ICG）清除试验是一个有价值的指标，肝transplants.MethodsWe进行ICG清除试验90脑死亡供体6小时内器官采购2015年3月至2016年11月之间。我们还分析了移植肝功能与肝移植（LT）后早期移植物存活的关系。结果我们的结果表明，供体在获取前15分钟ICG留存率（ICGR 15）与LT后3个月移植物存活独立相关。供体ICGR 15的最佳临界值为11.0%/min，并且我们观察到供体ICGR 15高于该值的患者中3个月移植失败的显著增加。另一方面，在一项研究中，供体ICGR 15值≤ 11.0%/min可作为移植物质量的早期评估指标，为移植外科医生或器官获取组织成员提供额外信息，以维持或改善器官功能以适应LT。结论肝获取前ICG清除率检测可作为预测移植物可用性和改善早期移植物的有效定量方法LT后的预后
BackgroundTransplantation centers have given much attention to donor availability. However, no reliable quantitative methods have been employed to accurately assess graft quality before transplantation. Here, we report that the indocyanine green (ICG) clearance test is a valuable index for liver grafts.MethodsWe performed the ICG clearance test on 90 brain-dead donors within 6 h before organ procurement between March 2015 and November 2016. We also analyzed the relationship between graft liver function and early graft survival after liver transplantation (LT).ResultsOur results suggest that the ICG retention rate at 15 min (ICGR15) of donors before procurement was independently associated with 3-month graft survival after LT. The best donor ICGR15 cutoff value was 11.0%/min, and we observed a significant increase in 3-month graft failure among patients with a donor ICGR15 above this value. On the other hand, a donor ICGR15 value of ≤ 11.0%/min could be used as an early assessment index of graft quality because it provides additional information to the transplant surgeon or organ procurement organization members who must maintain or improve organ function to adapt the LT.ConclusionAn ICG clearance test before liver procurement might be an effective quantitative method to predict graft availability and improve early graft prognosis after LT.