Brain activity evidence for recognition without recollection after early hippocampal damage
Brain activity evidence for recognition without recollection after early hippocampal damage
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DOI：
10.1073/pnas.131205798
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发表时间：
2001-07-03
影响因子：
11.1
通讯作者：
Mishkin, M
中科院分区：
文献类型：
--
作者：
Düzel, E;Vargha-Khadem, F;Mishkin, M
早期和看似孤立的海马损伤的痴呆患者表现出相对正常的识别记忆评分，这些患者的认知特征提出了这种识别表现主要是在缺乏回忆的背景信息的情况下通过刺激熟悉性来维持的可能性。在这里，我们报告了其中一名患者Jon的识别记忆状态的电生理数据，Jon对所研究单词的识别缺乏回忆的事件相关电位（ERP）指数，即，在正常受试者中可靠地诱发晚期阳性成分（500-700 ms）的条件下，晚期阳性成分增加。另一方面，在正常受试者中也可靠地发现的300和500 ms之间的ERP幅度的降低被很好地保存。这种所谓的N400效应在以前的ERP识别记忆研究中与刺激熟悉度有关。在乔恩，这一联系得到了以下发现的支持：他识别和未识别的研究单词在N400时间窗内诱发了地形上不同的ERP效应。这些数据表明，回忆比熟悉更依赖于海马结构，这与海马结构在情景记忆中起着特殊作用的观点一致，回忆对情景记忆至关重要。
Amnesic patients with early and seemingly isolated hippocampal injury show relatively normal recognition memory scores, The cognitive profile of these patients raises the possibility that this recognition performance is maintained mainly by stimulus familiarity in the absence of recollection of contextual information. Here we report electrophysiological data on the status of recognition memory in one of the patients, Jon, Jon's recognition of studied words lacks the event-related potential (ERP) index of recollection, viz., an increase in the late positive component (500-700 ms), under conditions that elicit it reliably in normal subjects. On the other hand, a decrease of the ERP amplitude between 300 and 500 ms, also reliably found in normal subjects, is well preserved. This so-called N400 effect has been linked to stimulus familiarity in previous ERP studies of recognition memory. In Jon, this link is supported by the finding that his recognized and unrecognized studied words evoked topographically distinct ERP effects in the N400 time window. These data suggest that recollection is more dependent on the hippocampal formation than is familiarity, consistent with the view that the hippocampal formation plays a special role in episodic: memory, for which recollection is so critical.