MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome
MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome
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DOI：
10.1016/s0925-4927(02)00066-5
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发表时间：
2002-11-30
影响因子：
2.3
通讯作者：
Kaufmann, WE
中科院分区：
文献类型：
--
作者：
Kates, WR;Frederikse, M;Kaufmann, WE
额叶-纹状体-丘脑-额叶回路功能障碍被认为是注意缺陷多动障碍（ADHD）和抽动秽语综合征（TS）的基础。因此，几个研究小组使用解剖磁共振成像（aMRI），以获得体积测量这些疾病的额叶分区。大多数以前的研究都依赖于subparcellation方法，利用胼胝体的地标，以获得额叶的分区。相比之下，我们在这里提出了一个可靠的额叶subparcellation协议的基础上，结合连续的沟/回边界，以获得额叶模块的基础上先前的功能研究的额叶形态测量ADHD和TS的调查。这个高度可靠的程序将额叶细分为五个主要模块：前额叶、运动前区、运动（中央前回）、前扣带回和深层白色物质。前四个模块也分为灰色和回白色物质隔间。该协议适用于T1加权，SPGR冠状MR 1图像的13名学龄男孩多动症，13名男孩TS，和13个年龄和性别匹配的对照。在多动症患者中，我们发现前额叶皮层的灰色和白色物质体积都减少了。这些研究结果，结合以前的报告基底神经节异常，表明，前额叶纹状体通路可能是异常的多动症。在TS中，我们发现左额深部白色物质体积减少。深部白色物质减少提示TS的长联合和投射纤维束存在异常。这项研究的结果证实并扩展了我们对ADHD和TS的神经生物学专栏4点短头文章Mp 2第2页第4帧的知识，表明提出的可靠的分组方法有可能增加我们对额叶在发育和精神障碍中的作用的理解。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Dysfunction of frontal-striatal-thalamic-frontal circuitry has been hypothesized to underlie both attention deficit hyperactivity disorder (ADHD) and Tourette syndrome (TS). Several research groups have therefore used anatomic magnetic resonance imaging (aMRI) to obtain volumetric measurements of subregions of the frontal lobe in these disorders. Most previous studies have relied on subparcellation methods that utilize callosal landmarks to derive subregions of the frontal lobe. In contrast, we present here an investigation of frontal lobe morphometry in ADHD and TS based on a reliable frontal subparcellation protocol that combines contiguous sulcal/gyral boundaries to derive frontal lobe modules based on prior functional studies. This highly reliable procedure subdivides the frontal lobe into five major modules: prefrontal, premotor, motor (precentral gyrus), anterior cingulate, and deep white matter. The first four modules are also segmented into gray and gyral white matter compartments. The protocol was applied to T1-weighted, SPGR coronal MR1 images of 13 school-aged boys with ADHD, 13 boys with TS, and 13 age- and gender-matched controls. In ADHD, we found volumetric reductions in both the gray and white matter of the prefrontal cortex. These findings, in conjunction with previous reports on basal ganglia abnormalities, suggest that prefrontal-striatal pathways may be anomalous in ADHD. In TS, we found volumetric decreases in the left deep frontal white matter. Decreases in deep white matter suggest the presence of abnormalities in long associational and projection fiber bundles in TS. The findings of this study both confirm and extend our knowledge of the neurobiology column 4 points shortbegin articleMp 2 page 2 frame 4of ADHD and TS, indicating that the reliable parcellation method presented has the potential of increasing our understanding of the role of the frontal lobe in developmental and psychiatric disorders. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.