Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Population Study (KOPS)
Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Population Study (KOPS)
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DOI：
10.1007/s00125-011-2310-6
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发表时间：
2011-12-01
期刊：
影响因子：
8.2
通讯作者：
Hayashi, J.
中科院分区：
文献类型：
--
作者：
Furusyo, N.;Koga, T.;Hayashi, J.
目的/假设糖化白蛋白是测量大约2-3周内平均血浆葡萄糖浓度的指标。我们确定了糖化白蛋白的参考值，并评估了其在普通人群中诊断2型糖尿病的效用。方法我们研究了1575名参加日本郊区城镇定期健康检查的男性和女性（平均年龄49.9岁，范围26-78岁）。测量HbA（1c）、空腹血浆葡萄糖（FPG）和糖化白蛋白浓度。FPG >= 7.0 mmol/l或HbA(1c) >= 6.5% （48 mmol/mol）的参与者被诊断为患有糖尿病。在我们的实验室中，糖化白蛋白检测的组内CVs和组间CVs分别为1.1%和1.6%。结果糖化白蛋白水平与HbA（1c）水平显著相关(r=0.766, p
Aims/hypothesis Glycated albumin is a measure of the mean plasma glucose concentration over approximately 2-3 weeks. We determined reference values for glycated albumin, and assessed its utility for the diagnosis of type 2 diabetes mellitus in the general population.Methods We studied 1,575 men and women (mean age, 49.9 years; range, 26-78 years) who participated in a periodic health examination in a suburban Japanese town. HbA(1c) and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG >= 7.0 mmol/l or HbA(1c) >= 6.5% (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1% and 1.6%, respectively.Results Glycated albumin levels were significantly correlated with HbA(1c) levels (r=0.766, p