ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches.
ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches.
复制标题
DOI：
10.1016/j.bbcan.2009.06.003
复制
发表时间：
2009-12
影响因子：
11.2
通讯作者：
Russo, Jose
中科院分区：
文献类型：
--
作者：
Chen, Jin-Qiang;Russo, Jose
关键词：
三阴性乳腺癌（TNBC）是一种缺乏雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体-2（HER-2）表达的侵袭性乳腺癌。TNBC患者约占乳腺癌患者总数的15%，在年轻的非洲人、非洲裔美国人和拉丁美洲妇女患者中更为普遍。目前可用的ER靶向和基于Her-2的疗法对于治疗TNBC无效。最近的研究揭示了TNBC的一些新特征。本研究对TNBC/基底细胞样乳腺癌的病理学特征、E2/ERβ介导的信号通路、G蛋白偶联受体30/上皮生长因子受体等进行了综述，并探讨了TNBC/基底细胞样乳腺癌的潜在治疗方法（GPCR-30/EGFR）信号通路; 4）ERβ与乳腺癌1/2（BRCA 1/2）的相互作用; 5）趋化因子CXCL 8和相关趋化因子; 6）改变的microRNA特征和micro-RNA对ERα表达/ERα信号的抑制; 7）几种促癌基因和肿瘤抑制蛋白的表达改变;和8）由氧化雌激素代谢物引起的遗传毒性作用。更好地了解TNBC中的这些分子途径可能会导致识别新的生物标志物和靶标，用于开发预防和治疗TNBC的诊断和治疗方法。
Triple negative breast cancer (TNBC) is a type of aggressive breast cancer lacking the expression of estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor-2 (HER-2). TNBC patients account for approximately 15% of total breast cancer patients and are more prevalent among young African, African-American and Latino women patients. The currently available ER-targeted and Her-2-based therapies are not effective for treating TNBC. Recent studies have revealed a number of novel features of TNBC. In the present work, we comprehensively addressed these features and discussed potential therapeutic approaches based on these features for TNBC, with particular focus on: 1) the pathological features of TNBC/basal-like breast cancer; 2) E2/ERβ – mediated signaling pathways; 3) G-protein coupling receptor-30/epithelial growth factor receptor (GPCR-30/EGFR) signaling pathway; 4) interactions of ERβ with breast cancer 1/2 (BRCA1/2); 5) chemokine CXCL8 and related chemokines; 6) altered microRNA signatures and suppression of ERα expression/ERα-signaling by micro-RNAs; 7) altered expression of several pro-oncongenic and tumor suppressor proteins; and 8) genotoxic effects caused by oxidative estrogen metabolites. Gaining better insights into these molecular pathways in TNBC may lead to identification of novel biomarkers and targets for development of diagnostic and therapeutic approaches for prevention and treatment of TNBC.
登录
查看更多内容
影响因子：
45.3
作者：
Atchley, Deann P.;Albarracin, Constance T.;Arun, Banu K.
通讯作者：
Arun, Banu K.
影响因子：
8
作者：
Fan, SJ;Ma, YX;Rosen, EM
通讯作者：
Rosen, EM
影响因子：
6.1
作者：
Chen, Yao;Ying, Lin;Wang Shen-Ming
通讯作者：
Wang Shen-Ming
影响因子：
4.8
作者：
Chang, Edmund C.;Frasor, Jonna;Katzenellenbogen, Benita S.
通讯作者：
Katzenellenbogen, Benita S.
DOI：
10.1016/j.bbamcr.2007.05.008
发表时间：
2007-12-01
影响因子：
5.1
作者：
Chen, Jin-Qiang;Russo, Patricia A.;Russo, Jose
通讯作者：
Russo, Jose