NeuroImage: Clinical Increased brain age in adults with Prader-Willi syndrome
NeuroImage: Clinical Increased brain age in adults with Prader-Willi syndrome
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NeuroImage：患有普瑞德威利综合征的成年人的临床大脑年龄增加
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通讯作者：
D. Hessl
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作者：
Stephanie M. Sansone;A. Schneider;E. Bickel;E. Berry;Christina Prescott;D. Hessl
Prader-Willi综合征（PWS）是最常见的遗传性肥胖综合征，伴有学习困难、神经内分泌缺陷、行为和精神问题。随着PWS患者预期寿命的增加，人们担心与该综合征相关的脑结构的改变，作为PWS基因表达缺失的直接结果，及其代谢并发症和激素缺乏，可能导致生理和脑老化的早期发作。在这项研究中，机器学习方法被用来预测大脑年龄的基础上，灰质（GM）和白色物质（WM）的地图来自结构神经成像数据使用T1加权磁共振成像（MRI）扫描。脑预测年龄差异（brain-PAD）评分，计算为实际年龄和脑预测年龄之间的差异，旨在反映与健康脑老化的偏差，较高的脑PAD评分表明过早老化。两个独立的成人队列进行脑预测年龄计算。主要队列中，PWS区域基因簇在结构性脑异常中主要与综合征和/或其并发症相关。需要进一步的纵向神经影像学研究来阐明PWS中脑年龄增加的自然史，其与肥胖的关系，以及是否在来自母亲单亲二体的PWS患者中观察到类似的发现。
Prader-Willi syndrome (PWS) is the most common genetic obesity syndrome, with associated learning diffi- culties, neuroendocrine deficits, and behavioural and psychiatric problems. As the life expectancy of individuals with PWS increases, there is concern that alterations in brain structure associated with the syndrome, as a direct result of absent expression of PWS genes, and its metabolic complications and hormonal deficits, might cause early onset of physiological and brain aging. In this study, a machine learning approach was used to predict brain age based on grey matter (GM) and white matter (WM) maps derived from structural neuroimaging data using T1-weighted magnetic resonance imaging (MRI) scans. Brain-predicted age difference (brain-PAD) scores, calculated as the difference between chronological age and brain-predicted age, are designed to reflect deviations from healthy brain aging, with higher brain-PAD scores indicating premature aging. Two separate adult cohorts underwent brain-predicted age calculation. The main cohort this PWS region gene cluster in the structural brain abnorm- alities associated primarily with the syndrome and/or its complications. Further longitudinal neuroimaging studies are needed to clarify the natural history of this increase in brain age in PWS, its relationship with obesity, and whether similar findings are seen in those with PWS from maternal uniparental disomy.