Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease.
Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease.
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DOI：
10.1111/j.1582-4934.2008.00314.x
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发表时间：
2008-06
影响因子：
5.3
通讯作者：
Frenkel D
中科院分区：
文献类型：
--
作者：
Farfara D;Lifshitz V;Frenkel D
阿尔茨海默病（AD）影响全球超过1800万人，其特征是进行性记忆缺陷、认知障碍和人格改变。AD的主要原因通常归因于淀粉样蛋白-β (Aβ)的产生和积累增加，与神经原纤维缠结（NFT）的形成有关。AD患者大脑中细胞因子、趋化因子等促炎因子水平升高，补体级联激活，促进老年斑引发局部炎症反应。根据流行病学研究结果显示，长期服用抗炎药物可降低阿尔茨海默病的患病率，以及来自临床材料研究的证据表明，在淀粉样斑块相同的区域，有活化的胶质细胞，特别是小胶质细胞和星形胶质细胞的积累，阿尔茨海默病中炎症成分的存在是众所周知的。神经胶质细胞维持大脑可塑性，保护大脑功能从损伤中恢复。神经胶质细胞的功能障碍可能促进神经退行性变，并最终导致神经元突触的收缩，从而导致认知缺陷。本文就阿尔茨海默病中的神经胶质细胞及其多样性特性进行综述。
Alzheimer's disease (AD) affects more than 18 million people worldwide and is characterized by progressive memory deficits, cognitive impairment and personality changes. The main cause of AD is generally attributed to the increased production and accumulation of amyloid-β (Aβ), in association with neurofibrillary tangle (NFT) formation. Increased levels of pro-inflammatory factors such as cytokines and chemokines, and the activation of the complement cascade occurs in the brains of AD patients and contributes to the local inflammatory response triggered by senile plaque. The existence of an inflammatory component in AD is now well known on the basis of epidemiological findings showing a reduced prevalence of the disease upon long-term medication with anti-inflammatory drugs, and evidence from studies of clinical materials that shows an accumulation of activated glial cells, particularly microglia and astrocytes, in the same areas as amyloid plaques. Glial cells maintain brain plasticity and protect the brain for functional recovery from injuries. Dysfunction of glial cells may promote neurodegeneration and, eventually, the retraction of neuronal synapses, which leads to cognitive deficits. The focus of this review is on glial cells and their diversity properties in AD.
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影响因子：
6
作者：
Coraci, IS;Husemann, J;El Khoury, JB
通讯作者：
El Khoury, JB
影响因子：
6.2
作者：
Bsibsi, M;Persoon-Deen, C;Van Noort, JM
通讯作者：
Van Noort, JM
影响因子：
82.9
作者：
Bard, F;Cannon, C;Yednock, T
通讯作者：
Yednock, T
影响因子：
4.8
作者：
Chen, KQ;Iribarren, P;Wang, JM
通讯作者：
Wang, JM
DOI：
10.1093/jnen/61.11.1013
发表时间：
2002-11-01
影响因子：
3.2
作者：
Bsibsi, M;Ravid, R;van Noort, JM
通讯作者：
van Noort, JM