Permanent impairment of spontaneous Purkinje cell discharge in cerebellar grafts caused by chronic lead exposure.
Permanent impairment of spontaneous Purkinje cell discharge in cerebellar grafts caused by chronic lead exposure.
复制标题
慢性铅暴露导致小脑移植物中自发性浦肯野细胞放电的永久性损伤。
DOI：
10.1016/0041-008x(81)90328-8
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发表时间：
1981
影响因子：
3.8
通讯作者：
Hoffer,BJ
中科院分区：
文献类型：
--
作者：
Palmer,MR;Björklund,H;Freedman,R;Taylor,DA;Marwaha,J;Olson,L;Seiger,A;Hoffer,BJ
采用大鼠小脑移植物，研究了围产期铅暴露对发育期大鼠脑的影响。在饮用水中加入1%的醋酸铅，移植物的组织学组织几乎没有变化。与此形成鲜明对比的是，几乎所有的浦肯野细胞自发放电是在这些移植物缺席。即使在记录和停止铅治疗之间已经过去了4-5个月，也可以看到这一点。醋酸钠处理的动物移植浦肯野细胞的电生理特性没有改变。此外，在原位小脑浦肯野细胞在两组动物正常放电。这些数据表明，铅的管理，引发450-550微克/升的血液水平，产生了一个长期的选择性电生理缺陷，在发育中的大脑在oculo。
The effects of perinatal lead administration on developing rat brain were studied using cerebellar grafts in oculo. Using 1% lead acetate in the drinking water, little change was seen in the histological organization of the graft. In marked contrast, virtually all Purkinje cell spontaneous discharge was absent in these grafts. This was seen even though 4–5 months had elapsed between recording and the cessation of lead treatment. There was no alteration in electrophysiological properties of transplant Purkinje cells from sodium acetate-treated animals. Moreover, host in situ cerebellar Purkinje cells in both groups of animals discharged normally. These data indicate that lead administration, eliciting blood levels of 450–550 μg/liter, produces a long-lasting selective electrophysiological deficit in developing brain in oculo.