Effect of Dexamethasone on Luteinizing Hormone and Follicle Stimulating Hormone Responses to LHRH and to Clomiphene in the Follicular Phase of Women with Normal Menstrual Cycles
Effect of Dexamethasone on Luteinizing Hormone and Follicle Stimulating Hormone Responses to LHRH and to Clomiphene in the Follicular Phase of Women with Normal Menstrual Cycles
复制标题
地塞米松对正常月经周期女性卵泡期黄体生成素和卵泡刺激素对 LHRH 和克罗米芬反应的影响
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
S. Blanchard
中科院分区：
文献类型：
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作者：
J. Sowers;B. Rice;S. Blanchard
为阐明糖皮质激素抑制下丘脑-垂体-卵巢轴的作用机制，我们研究了短期大剂量地塞米松治疗对正常月经周期健康女性促黄体生成素(LHRH)和促卵泡激素释放激素(FSH)反应的影响。7名女性，21-35岁，接受了100微克的LHRH静脉注射。在连续两个月经周期的第6天，每6小时口服一次地塞米松2 mg，一次不用地塞米松。在月经周期的第2天到第5天。另外7名女性(年龄21-35岁)在月经周期的第2天至第5天服用克罗米芬100 mg，每6小时一次和一次不同时口服地塞米松2 mg。地塞米松的应用抑制了基线血清黄体生成素和卵泡刺激素水平，并减弱了黄体生成素和卵泡刺激素对LHRH和克罗米芬的反应。结果表明，短期给予药理剂量的糖皮质激素可直接作用于垂体前叶，并可能通过抑制LHRH的释放而抑制下丘脑水平的促黄体生成素和卵泡刺激素的分泌。
In an attempt to elucidate the mechanism of suppressive action of glucocorticoids on the hypothalamo-pituitary-ovarian axis, we studied the effects of short-term high dose dexamethasone administration of the LH and FSH responses to LHRH and to clomiphene in healthy women with normal menstrual cycles. Seven women, 21--35 years of age, received 100 micrograms of LHRH i.v. on day 6 of two consecutive menstrual cycles, once with and once without pre-treatment with dexamethasone 2 mg orally every 6 hrs. on days 2 through 5 of the menstrual cycle. Seven other women (ages 21--35 years) received clomiphene citrate 100 mg on days 2 through 5 of their menstrual cycle, once with and once without simultaneous administration of dexamethasone 2 mg orally every 6 h. The administration of dexamethasone suppressed baseline serum levels of LH and FSH and blunted LH and FSH response to both LHRH and clomiphene. The results indicate that short-term administration of pharmacological doses of glucocorticoids suppress the secretion of LH and FSH by a direct effect on the anterior pituitary and possibly by an effect at the hypothalamic level with inhibition of the release of LHRH.