Combined chemotherapy plus radiotherapy for treatment of earlystage intermediate- and high-grade non-Hodgkin’s lymphoma
Combined chemotherapy plus radiotherapy for treatment of earlystage intermediate- and high-grade non-Hodgkin’s lymphoma
复制标题
联合化疗加放疗治疗早期中高度恶性非霍奇金淋巴瘤
作者：
J. Briggs;T. Miller
局部侵袭性非霍奇金淋巴瘤（I期、IE期、非大体积II期和IIE期）的治疗方法在过去20年中不断发展。在1980年之前，这些疾病被证明可以通过放疗局部控制，但全身复发和死亡很常见。随着含有阿霉素的化疗的潜在疗效的发现，20世纪80年代的初步研究表明，通过增加治愈患者的比例，联合化疗作为初始治疗的效用。在20世纪90年代，两项大型随机前瞻性试验通过确定初始化疗后放射治疗（联合模式治疗）为当前可用的最佳治疗策略，为未来的比较设定了基准。
Treatment of localized (stages I, IE, non-bulky II and IIE) aggressive histologies of non-Hodgkin’s lymphoma has evolved over the past 20 years. Prior to 1980, these diseases were shown to be locally controlled with radiotherapy, but systemic relapse and death were common. With the discovery of potentially curative doxorubicin-containing chemotherapy, pilot studies during the 1980s demonstrated the utility of combination chemotherapy as initial therapy by increasing the proportion of cured patients. In the 1990s, two large randomized, prospective trials set the benchmark for future comparisons by establishing initial chemotherapy followed by radiation therapy (combined modality therapy) as the best available current treatment strategy.
影响因子：
158.5
作者：
Miller, TP;Dahlberg, S;Fisher, RI
通讯作者：
Fisher, RI
影响因子：
158.5
作者：
FISHER, RI;GAYNOR, ER;MILLER, TP
通讯作者：
MILLER, TP