Resting state networks of awake adolescent and adult squirrel monkeys using ultra-high field (9.4T) functional magnetic resonance imaging.
Resting state networks of awake adolescent and adult squirrel monkeys using ultra-high field (9.4T) functional magnetic resonance imaging.
复制标题
使用超高场 (9.4T) 功能磁共振成像显示清醒的青少年和成年松鼠猴的静息状态网络。
DOI：
10.1101/2023.01.08.523000
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Kohut,StephenJ
中科院分区：
文献类型：
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作者：
Yassin,Walid;deMoura,FernandoB;Withey,SarahL;Cao,Lei;Kangas,BrianD;Bergman,Jack;Kohut,StephenJ
静息状态网络(RSNs)作为神经精神障碍的候选生物标志物越来越受到重视。这些生物标志物可能为评估经常用于转译神经成像研究的非人类灵长类动物的新的治疗干预措施提供客观的衡量标准。这项研究旨在描述清醒松鼠猴的RSNs特征，并比较青少年和成年受试者中这些网络的特征。2 7只松鼠猴[n= 12只青少年(6雄/6雌)∼2.5 岁和n= 15只成年(7雄8雌)∼9.5 岁]逐渐适应清醒扫描程序，用9.4 T扫描仪采集全脑功能磁共振图像。组级独立成分分析(ICA；30个IC)和双回归用于检测和比较RSNs。在青春期和成年猴中都鉴定出了20个IC，它们对应于代表一系列神经功能的生理意义网络，包括运动、感觉、奖励和认知过程。这些RSN的重复性在几个ICA模型订单上进行了评估。与青少年受试者相比，成年人在两个感兴趣的网络上表现出更强的连通性：(1)在右侧枕叶区域与OFC网络；(2)在左侧颞叶皮质、双侧枕叶皮质和小脑与后扣带网络。然而，当年龄进入上述模型时，这种有意义的趋势就消失了。这些结果表明，松鼠猴RSNs是稳定的，并与以前在人类、啮齿动物和其他非人类灵长类物种中发现的RSNs一致。这些数据还确定了青春期的几个网络是保守的，以及其他可能转变为成年的网络。
Resting-state networks (RSNs) are increasingly forwarded as candidate biomarkers for neuropsychiatric disorders. Such biomarkers may provide objective measures for evaluating novel therapeutic interventions in nonhuman primates often used in translational neuroimaging research. This study aimed to characterize the RSNs of awake squirrel monkeys and compare the characteristics of those networks in adolescent and adult subjects. Twenty-seven squirrel monkeys [n= 12 adolescents (6 male/6 female) ∼2.5 years andn= 15 adults (7 male/8 female) ∼9.5 years] were gradually acclimated to awake scanning procedures; whole-brain fMRI images were acquired with a 9.4 T scanner. Group-level independent component analysis (ICA; 30 ICs) with dual regression was used to detect and compare RSNs. Twenty ICs corresponding to physiologically meaningful networks representing a range of neural functions, including motor, sensory, reward, and cognitive processes, were identified in both adolescent and adult monkeys. The reproducibility of these RSNs was evaluated across several ICA model orders. Adults showed a trend for greater connectivity compared with adolescent subjects in two of the networks of interest: (1) in the right occipital region with the OFC network and (2) in the left temporal cortex, bilateral occipital cortex, and cerebellum with the posterior cingulate network. However, when age was entered into the above model, this trend for significance was lost. These results demonstrate that squirrel monkey RSNs are stable and consistent with RSNs previously identified in humans, rodents, and other nonhuman primate species. These data also identify several networks in adolescence that are conserved and others that may change into adulthood.