Obstetrics and Neonatal Outcomes in Pregnant Women with COVID-19: A Systematic Review.
Obstetrics and Neonatal Outcomes in Pregnant Women with COVID-19: A Systematic Review.
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DOI：
10.18502/ijph.v49is1.3668
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发表时间：
2020-10
影响因子：
1.4
通讯作者：
Rokni M
中科院分区：
文献类型：
--
作者：
Banaei M;Ghasemi V;Saei Ghare Naz M;Kiani Z;Rashidi-Fakari F;Banaei S;Mohammad Souri B;Rokni M
考虑到产科医生和儿科医生需要全面了解COVID-19对产科和新生儿的影响，因此进行了这项回顾性研究，以调查COVID-19对产科和新生儿结局的影响。在本系统性综述中，检索了PubMed、Web of Science、Scopus、ProQuest和Embase以及Google scholar之后的国际检索数据库。所有文章均由两名独立研究人员审查，直至2020年4月10日。对纳入研究进行质量评估后，在2个部分中报告了产科和新生儿结局。评估了16项研究，样本量为123名确诊为COVID-19的孕妇及其新生儿。孕龄25-40周。孕妇中没有与COVID-19相关的死亡。COVID-19孕妇的产科结局包括胎动减少、胎儿宫内窘迫、贫血、胎膜早破、早产、多器官功能障碍综合征（MODS）等。除一例MODS外，在大多数回顾的研究中，未发生严重的并发症或死亡。新生儿结局为死产、早产、窒息、胎儿窘迫、低出生体重、小于胎龄儿、大于胎龄儿、多器官功能障碍综合征、弥漫性血管内凝血和新生儿死亡。此外，患有COVID-19的母亲所生的5名新生儿SARS-CoV-2呈阳性。然而，研究报告了这些结果，但主题的确切原因尚不清楚。在这篇系统性综述中，我们总结了COVID-19后产科和新生儿结局的各种研究结果。这种感染可能会导致母亲和新生儿的负面结果。然而，有证据表明新生儿感染了COVID-19，但关于COVID-19的垂直传播存在争议。
Considering that the obstetricians and pediatricians need to comprehensive information about the obstetric and neonatal effect of COVID-19, this review study was conducted to investigate the impact of COVID-19 on obstetrics and neonatal outcomes. In this systematic review the international search databases following PubMed, Web of Science, Scopus, ProQuest and Embase and Google scholar were searched. All articles were reviewed by two independent researchers until 10 April 2020. After quality assessment of included studies the finding reported in 2 sections obstetrics and neonatal outcomes. The sixteen studies with a sample size of 123 pregnant women with a definitive diagnosis of COVID-19 and their neonates were evaluated. The range of gestational age was 25–40 weeks. There was no death associated with COVID-19 in pregnant women. The obstetric outcomes in pregnant women with COVID-19 include decreased fetal movement, intrauterine fetal distress, anemia, PROM, preterm labor, Multiple Organ Dysfunction Syndrome (MODS) and etc. The most common delivery mode in women affect with COVID-19 was cesarean section. Expect for one case with MODS, in the majority of the studies reviewed, no severe morbidity or mortality occurred. The neonatal outcomes were stillbirth, prematurity, asphyxia, fetal distress, low birth weight, small for gestational age, large for gestational age, multiple organ dysfunction syndrome, disseminated intravascular coagulation and neonatal death. In addition, five neonates born to mothers with COVID-19 were positive for SARS-CoV-2. However, the studies report these outcomes but the exact causes of theme are not known. In this systematic review, we summarize the diverse results of studies about the obstetrics and neonatal outcomes following COVID-19. This infection may cause negative outcomes in both mothers and neonates. However, there were evidence about neonate infected with COVID-19, but there is controversial information about the vertical transmission of COVID-19.