Spatial Patterning of Tissue Volume Loss in Schizophrenia Reflects Brain Network Architecture
Spatial Patterning of Tissue Volume Loss in Schizophrenia Reflects Brain Network Architecture
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DOI：
10.1016/j.biopsych.2019.09.031
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发表时间：
2020-04-15
影响因子：
10.6
通讯作者：
Misic, Bratislav
中科院分区：
文献类型：
--
作者：
Shafiei, Golia;Markello, Ross D.;Misic, Bratislav
背景：越来越多的人认识到，在一系列神经和精神疾病中，连接体结构会影响皮层和皮层下灰质萎缩。连通性是否以同样的方式导致精神分裂症的组织体积损失尚不清楚。方法：在这里，我们将精神分裂症患者的组织体积损失与结构和功能连接模式联系起来。对133名慢性精神分裂症患者（48名女性，平均年龄34.7 +/- 12.9岁）和113名对照受试者（64名女性，平均年龄23.5 +/- 8.4岁）的灰质变形进行了估计。基于变形的形态测量法用于从t1加权磁共振图像中估计皮层和皮层下灰质变形。使用扩散谱成像和静息状态功能磁共振成像，从70名健康参与者的独立样本中获得结构和功能连接模式。结果：我们发现区域变形与结构和功能连接的邻居的变形相关。分布的变形模式由特定的功能系统（腹侧注意网络）和细胞结构类别（边缘类）限定，震中位于前扣带皮层。结论：总的来说，本研究表明，精神分裂症患者的脑组织体积损失是由结构和功能连通性决定的，占区域变形差异的25%至35%。
BACKGROUND: There is growing recognition that connectome architecture shapes cortical and subcortical gray matter atrophy across a spectrum of neurological and psychiatric diseases. Whether connectivity contributes to tissue volume loss in schizophrenia in the same manner remains unknown.METHODS: Here, we relate tissue volume loss in patients with schizophrenia to patterns of structural and functional connectivity. Gray matter deformation was estimated in a sample of 133 individuals with chronic schizophrenia (48 women, mean age 34.7 +/- 12.9 years) and 113 control subjects (64 women, mean age 23.5 +/- 8.4 years). Deformation-based morphometry was used to estimate cortical and subcortical gray matter deformation from T1-weighted magnetic resonance images. Structural and functional connectivity patterns were derived from an independent sample of 70 healthy participants using diffusion spectrum imaging and resting-state functional magnetic resonance imaging.RESULTS: We found that regional deformation is correlated with the deformation of structurally and functionally connected neighbors. Distributed deformation patterns are circumscribed by specific functional systems (the ventral attention network) and cytoarchitectonic classes (limbic class), with an epicenter in the anterior cingulate cortex.CONCLUSIONS: Altogether, the present study demonstrates that brain tissue volume loss in schizophrenia is conditioned by structural and functional connectivity, accounting for 25% to 35% of regional variance in deformation.