Vasopressin agonists and antagonists.
Vasopressin agonists and antagonists.
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加压素激动剂和拮抗剂。
DOI：
10.1159/000181810
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Thibonnier,M
中科院分区：
文献类型：
--
作者：
Thibonnier,M
在这篇文章中，血管加压素分子的结构的离散修改，导致特定的V1血管，V2肾，和混合V1/V2类似物的发展进行了审查。特别地，提供了通过羧基末端的缺失和取代产生的第三代加压素拮抗剂，以及通过分子的缺失、取代和线性化获得的第四代加压素拮抗剂。这些不同的化合物的潜在优势说明了我们的工作对V1血管加压素受体的人血小板。
In this article, the discrete modifications of the structure of the vasopressin molecule which led to the development of specific V1vascular, V2renal, and mixed V1/V2analogs are reviewed. Particularly, the third generation of vasopressin antagonists produced by deletions and substitutions of the carboxy terminal, and the fourth generation of vasopressin antagonists obtained by deletions, substitutions, and the linearization of the molecule are presented. The potential advantages of these different compounds are illustrated by our work on V1vascular vasopressin receptors of human platelets.