Blunting of TSH response after repeated oral administration of TRH in normal and hypothyroid subjects.
Blunting of TSH response after repeated oral administration of TRH in normal and hypothyroid subjects.
复制标题
正常和甲状腺功能减退受试者重复口服 TRH 后 TSH 反应减弱。
DOI：
--
复制
发表时间：
1978
影响因子：
5.8
通讯作者：
E. Gemsenjaeger
中科院分区：
文献类型：
--
作者：
J. Staub;J. Girard;J. Mueller‐Brand;B. Noelpp;I. Werner;U. Baur;P. Heitz;E. Gemsenjaeger
在甲状腺功能正常的受试者中，重复口服 TRH 会比单次口服 TRH 产生更大的血浆甲状腺素 (T4) 和三碘甲状腺原氨酸 (T3) 水平增加。相反，TSH 反应减弱。为了确定这种反应减弱是否是由负反馈机制介导的，我们比较了单次和重复口服 TRH 对甲状腺功能正常受试者和原发性甲状腺功能衰竭患者的 TSH、T3 和 T4 反应的影响。 35 名甲状腺功能正常的受试者在 26 小时内口服 3 次 40 mg TRH。平均 TSH 峰值从第 1 次给药后的 13.0 µU/ml 下降至第 3 次给药后的 5.9 µU/ml (P < 0.0005)。第 3 剂 TRH 后 3 小时，T4 浓度从基础 7.5 µg/100 ml 增加至 10.2 µg/100 ml，T3 浓度从 1.52 ng/ml 增加至 2.19 ng/ml。 9 名原发性甲状腺功能减退症患者和 9 名因甲状腺癌接受全甲状腺消融后的患者也重复口服 TRH。第三次口服 TRH 后，TSH 反应同样显着减弱......
In euthyroid subjects, repeated oral doses of TRH produced a greater increase of plasma levels of thyroxine (T4) and triiodothyronine (T3) than did a single dose. The TSH response, in contrast, was diminished. To determine if this blunting of the response was mediated by a negative feedback mechanism, we compared the effects of single and repeated oral doses of TRH on TSH, T3, and T4 responses in euthyroid subjects and in patients with primary thyroid failure. Thirty-five euthyroid subjects were given 3 oral doses of 40 mg TRH over a period of 26 h. The mean TSH peak declined from 13.0 µU/ml after the 1st dose to 5,9 µU/ml after the 3rd dose (P < 0.0005). T4 concentrations increased from basal 7.5 to 10.2 µg/100 ml 3 h after the 3rd dose of TRH and T3 from 1.52 to 2.19 ng/ml. Repeated oral doses of TRH were also given to 9 patients with primary hypothyroidism and 9 patients after total thyroid ablation for thyroid carcinoma. The same significant blunting of the TSH response after the 3rd oral dose of TRH ...