Analysis of biomolecule detection with optofluidic ring resonator sensors
Analysis of biomolecule detection with optofluidic ring resonator sensors
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DOI：
10.1364/oe.15.009139
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发表时间：
2007-07-23
期刊：
影响因子：
3.8
通讯作者：
Fan, Xudong
中科院分区：
文献类型：
--
作者：
Zhu, Hongying;White, Ian M.;Fan, Xudong
本文从理论和实验上分析了液芯光学环形谐振腔（LCORR）作为一种无标记生物/化学传感器的生物分子检测能力。我们首先建立一个简单的和一般的线性关系LCORR的体积折射率灵敏度（BRIS）和它的响应分子沉积到表面上，这使我们能够很容易地表征LCORR传感性能。然后，生物传感实验进行与牛血清白蛋白（BSA）和LCORR的各种BRIS。实验结果与理论预测吻合较好。进一步分析表明，LCORR能够检测低于10 pM的BSA，质量检测限为亚皮克/mm（2）。(C)2007年，美国光学学会。
We theoretically and experimentally analyze the biomolecule detection capability of the liquid core optical ring resonator (LCORR) as a label-free bio/chemical sensor. We first establish a simple and general linear relationship between the LCORR's bulk refractive index sensitivity (BRIS) and its response to molecule deposition onto the surface, which enables us to easily characterize the LCORR sensing performance. Then, biosensing experiments are performed with bovine serum albumin (BSA) and LCORRs of various BRISs. The experimental results are in good agreement with the theoretical prediction. Further analysis shows that the LCORR is capable of detecting BSA below 10 pM with sub-picogram/mm(2) mass detection limit. (C) 2007 Optical Society of America.