Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis:: the role of leukotriene B4
Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis:: the role of leukotriene B4
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DOI：
10.1034/j.1399-3003.2000.15b09.x
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发表时间：
2000-02-01
影响因子：
24.3
通讯作者：
Stockley, RA
中科院分区：
文献类型：
--
作者：
Crooks, SW;Bayley, DL;Stockley, RA
在慢性阻塞性肺疾病（COPD）中，被募集到气道的中性粒细胞被认为介导组织破坏。在细菌加重期间，神经元募集增加。研究了COPD急性加重患者的炎症过程，以确定白细胞三烯B-4（LTB 4）的作用。分析了8名COPD细菌性加重受试者的痰中中性粒细胞产物（髓过氧化物酶、弹性蛋白酶）和化学引诱物（白细胞介素-8（IL-8）和LTB 4）。使用LTB 4受体拮抗剂LY 293111测定LTB 4对痰液溶胶相的趋化活性的贡献。测定血清急性时相蛋白α（1）-蛋白酶抑制剂、α（1）-抗糜蛋白酶和C-反应蛋白的浓度。所有患者均接受适当的广谱抗生素治疗7-14天。最初，痰髓过氧化物酶活性高，表明中性粒细胞流入;这与高水平的IL-8和LTB 4相关。所有这些浓度均随治疗而下降（p
Neutrophils recruited to the airways in chronic obstructive pulmonary disease (COPD) are thought to mediate tissue destruction. Neutrophil recruitment is increased during bacterial exacerbations. The inflammatory process was studied in patients with an acute exacerbation of COPD in order to ascertain the role of leukotriene B-4 (LTB4).The sputum of eight subjects with a bacterial exacerbation of COPD was analysed for neutrophil products (myeloperoxidase, elastase) and chemoattractants (interleukin-8 (IL-8) and LTB4). The contribution of LTB4 to the chemotactic activity of the sputum sol phase was determined using the LTB4 receptor antagonist LY293111. The concentrations of the serum acute phase proteins alpha(1)-proteinase inhibitor, alpha(1)-antichy-motrypsin and C-reactive protein were measured. All patients received appropriate broad-spectrum antibiotic treatment for 7-14 days.Initially, the sputum myeloperoxidase activity was high, indicating neutrophil influx; this was associated with high levels of IL-8 and LTB4. All these concentrations fell with treatment (p