Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field
Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field
复制标题
DOI：
10.1007/s10585-007-9068-8
复制
发表时间：
2007-01-01
影响因子：
4
通讯作者：
Uchida, Atsurnasa
中科院分区：
文献类型：
--
作者：
Matsumine, Akihiko;Kusuzaki, Katsuyuki;Uchida, Atsurnasa
我们开发了一种使用磁性材料治疗转移性骨肿瘤的新型高温治疗方式。本研究的目的是显示新的热疗转移性骨肿瘤的结果。这种新的热疗方式被用于15例患者的16个骨转移病灶。在7个病灶中，转移病灶刮除后，用金属髓内钉或钢板加固，将含有粉末状Fe3O4的磷酸钙骨水泥（CPC）植入腔内。在一个病变，假体重建，然后进行病灶内肿瘤切除术后。对于其余8处病变，将金属髓内钉插入受影响的骨中。术后1周开始热疗。为了比较评估接受热疗患者（HT组）的放射学结果，我们还评估了8例接受姑息手术而不进行放疗或热疗的患者（Op组）和22例接受手术联合术后放疗的患者（Op + RT组）。HT组患者术后肢体功能恢复良好，疼痛缓解，无并发症发生。在X线片上，HT组、Op组和Op + RT组中分别有87%、38%和91%的患者被认为显示了有效的治疗结局。HT组患者的影像学结局优于Op组（P = 0.0042）。HT组与Op + RT组比较，差异无统计学意义（P = 0.412）。这是第一个临床热疗系列使用磁性材料取得了良好的局部控制转移性骨病变。
We have developed a novel hyperthermic treatment modality using magnetic materials for metastatic bone tumors. The purpose of this study is to show the results of novel hyperthermia for metastatic bone tumors. This novel hyperthermic treatment modality was used for 15 patients with 16 metastatic bone lesions. In seven lesions, after curettage of the metastatic lesion followed by reinforcement with a metal intramedullary nail or plate, calcium phosphate cement (CPC) containing powdery Fe3O4 was implanted into the cavity. In one lesion, prosthetic reconstruction was then performed after an intralesional tumor excision. For the remaining eight lesions, metal intramedullary nails were inserted into the affected bone. Hyperthermic therapy was started at I week postoperatively. To comparatively evaluate the radiographic results of patients who underwent hyperthermia (HT group), we also assessed eight patients who received a palliative operation without either radiotherapy or hyperthermia (Op group), and 22 patients who received operation in combination with postoperative radiotherapy (Op + RT group). In HT group, all patients had an acceptable limb function with pain relief without any complications. On radiographs, 87, 38, and 91% were, respectively, considered to demonstrate an effective treatment outcome in HT group, Op group, and Op + RT group. The patients in HT group showed a statistically better radiographic outcome than the patients in Op group (P = 0.0042). But when compared between HT group and Op + RT group, there were no significant difference (P = 0.412). This first series of clinical hyperthermia using magnetic materials achieved good local control of metastatic bone lesion.