Double-stranded RNA adenosine deaminase as a potential mammalian RNA editing factor.
Double-stranded RNA adenosine deaminase as a potential mammalian RNA editing factor.
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DOI：
10.1006/scel.1993.1034
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发表时间：
1993-08
期刊：
影响因子：
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通讯作者：
Unkyu Kim;K. Nishikura
中科院分区：
文献类型：
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作者：
Unkyu Kim;K. Nishikura
双链RNA（dsRNA）腺苷脱氨酶（英语：Adenosine deaminase），简称DRDA，是一种细胞酶，通过水解脱氨作用将dsRNA中的腺苷残基修饰为肌苷，用错配的I-U碱基对取代A-U。由于它改变了其底物RNA中的碱基组成，DRDA扮演的一个可能的角色是参与RNA编辑。本文简要介绍了DRDA的特点。它可能参与RNA编辑也进行了详细讨论，包括具体的情况下，其中DRADA已牵连作为RNA编辑因子。
Double-stranded RNA (dsRNA) adenosine deaminase, or DRADA, is a cellular enzyme that modifies adenosine residues to inosines in dsRNA by hydrolytic deamination, replacing A-U with mismatched I-U base pairs. Since it alters the base composition in its substrate RNA, one possible role played by DRADA is to participate in RNA editing. In this article, a brief review is given of characteristics of DRADA. Its possible involvement in RNA editing is also discussed in detail, including specific cases in which DRADA has been implicated as an RNA editing factor.