The effect of body mass index on survival in advanced epithelial ovarian cancer.
The effect of body mass index on survival in advanced epithelial ovarian cancer.
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DOI：
10.3346/jkms.2014.29.6.793
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发表时间：
2014-06
影响因子：
4.5
通讯作者：
Kim YM
中科院分区：
文献类型：
--
作者：
Bae HS;Hong JH;Ki KD;Song JY;Shin JW;Lee JM;Lee JK;Lee NW;Lee C;Lee KW;Kim YM
关于肥胖对亚洲卵巢癌患者生存率的影响仍存在争议。本研究采用亚洲人体重指数（BMI）标准检测肥胖对晚期上皮性卵巢癌（EOC）患者生存结局的影响。回顾了晚期（III期和IV期）EOC手术患者的病历。统计学分析包括方差分析、卡方检验、Kaplan-Meier生存分析和考克斯回归分析。在所有236例患者中，除了体重不足的患者外，根据BMI的总生存率没有差异。在多变量考克斯分析中，手术最佳性和体重过轻状态是独立且重要的生存预后因素（分别为HR，2.302; 95% CI，1.326-3.995; P=0.003和HR，8.622; 95% CI，1.871-39.737; P = 0.006）。在浆液性组织学和最佳手术的亚组中，超重和肥胖I型患者的生存率高于正常体重患者（P = 0.012）。我们发现，体重过轻的BMI和手术最佳性是晚期卵巢癌患者生存的独立危险因素。高BMI组（超重、肥胖I和II）与晚期EOC患者的生存率无关。但在浆液性卵巢癌患者中，手术后超重和肥胖I组患者的生存率明显高于正常体重组。
Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients.