Local field potentials get funny.
Local field potentials get funny.
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局部场潜力变得有趣。
DOI：
10.1113/jp272673
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发表时间：
2016-07-01
期刊：
影响因子：
--
通讯作者：
Nolan MF
中科院分区：
文献类型：
--
作者：
Nolan MF
局域场势(LFP)在实验中被广泛用于指示大脑皮层活动和信息处理。使用LFP记录的经典研究包括第一次展示长时程增强(Bliss&Lomo，1973)和对振荡大脑状态的描述(Buzsaki&Draguhn，2004)，而最近的应用扩展到通过间接监测单个神经元活动来控制脑机接口(Hall等人)。2014年)。LFP记录的力量来自于它们高的时间和空间分辨率，以及它们可以相对容易地获得。令人惊讶的是，考虑到它们的长期重要性，直到最近才开始广泛研究决定大脑皮层LFP波形的离子机制(Buzsaki等人)。2012年)。长期以来，LFP通常被认为主要是通过锥体细胞膜上的突触受体反映电流。然而，膜电流也是由电压门控离子通道携带的。这些活跃的膜电导负责动作电位的产生和突触反应的整合。最近的模拟研究表明，调节动作电位放电的电压调节的Na+和K+通道对LFP有重要影响(Reimannet al.2013)，但在低于动作电位阈值的膜电位下，介导突触整合的离子通道的作用尚不清楚。
The local field potential (LFP) is widely used experimentally to index cortical activity and information processing. Classic studies using recordings of LFPs include the first demonstration of long-term potentiation (Bliss & Lomo, 1973) and descriptions of oscillatory brain states (Buzsaki & Draguhn, 2004), while more recent applications extend as far as control of brain–machine interfaces by indirect monitoring of single neurone activity (Hall et al. 2014). The power of LFP recordings comes from both their high temporal and spatial resolution, and the relative ease with which they can be obtained.Surprisingly, given their long-standing importance, it is only relatively recently that the ionic mechanisms that determine the waveform of cortical LFPs have begun to be extensively scrutinized (Buzsaki et al. 2012). For a long time LFPs were often assumed to primarily reflect currents through synaptic receptors in the membrane of pyramidal cells. However, membrane currents are also carried by voltage-gated ion channels. These active membrane conductances are responsible for generation of action potentials and for integration of synaptic responses. Recent modelling studies suggest important influences on the LFP of voltagegated Na+ and K+ channels that mediate action potential firing (Reimannet al. 2013), but the contributions of ion channels that mediate synaptic integration at membrane potentials below the action potential threshold have remained unclear.