Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis
Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis
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DOI：
10.1016/j.jneuroim.2011.12.008
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发表时间：
2012-02-29
影响因子：
3.3
通讯作者：
Cheng, Qi
中科院分区：
文献类型：
--
作者：
Chen, Ying-Chun;Chen, Sheng-Di;Cheng, Qi
研究表明，细胞因子在多发性硬化（MS）的发病机制中起重要作用。本研究旨在探讨MS患者血清中IL-18、IL-23和IL-17的水平。比较了39例MS患者和39例年龄、性别相匹配的健康对照者血清中促炎细胞因子IL-18、IL-23和IL-17的水平。采用流式细胞仪（FlowCytomix）检测血清细胞因子。研究了血清三种细胞因子水平与残疾（扩展残疾状态量表，EDSS）、疾病持续时间、当前年龄和发病年龄之间的相关性。MS患者血清IL-18、IL-23和IL-17浓度均显著高于健康对照组。男性MS患者血清IL-18水平显著高于女性（P=0.049）。三种细胞因子水平与EDSS评分、病程及年龄均无相关性。然而.男性MS患者IL-23水平与发病年龄呈负相关（r（s）=-0.775，P =0.041）。我们的数据表明，所有IL-18。IL-23和IL-17可能参与了MS的发病过程，但这三种细胞因子与MS临床特征的关系有待进一步研究。(C)2011 Elsevier BY. All rights reserved.
It has been reported that cytokines play an important role in the pathogenesis of multiple sclerosis (MS). The aim of this study was to evaluate the serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with MS. We compared the serum concentrations of pro-inflammatory cytokines IL-18, IL-23 and IL-17 in 39 patients with MS and 39 healthy controls matched with sex and age. Serum cytokines were measured by FlowCytomix, a kind of cytometric bead-based assay. Correlations between the serum levels of the three cytokines and disability (expanded disability status scale, EDSS), disease duration, current age and age at onset were examined. Serum concentrations of all IL-18, IL-23 and IL-17 were significantly higher in MS patients than healthy controls. There were no significant differences of the three cytokines' levels between female and male healthy controls, while the serum IL-18 level was observed significantly higher (P=0.049) in male MS patients than female MS patients. No significant correlations were observed between any of the three cytokines' levels and EDSS, disease duration and current age. However. IL-23 was found negatively correlated with age at onset in male MS patients (r(s)=-0.775, P=0.041). Our data suggest that all IL-18. IL-23 and IL-17 may be involved in the pathogenesis of MS. However, the relationships of the three cytokines and clinical characteristics of MS need to be further investigated in the future. (C) 2011 Elsevier BY. All rights reserved.